DIETARY EXPOSURE EFFECT OF SUBLETHAL DOSES OF METHOMYL ON GROWTH PERFORMANCE AND BIOCHEMICAL CHANGES IN RABBITS AND THE PROTECTIVE ROLE OF VITAMIN E PLUS SELENIUM | ||||
| Egyptian Journal of Rabbit Science | ||||
| Article 4, Volume 25, Issue 1, January 2015, Page 59-81 PDF (192.06 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrs.2015.46698 | ||||
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| Authors | ||||
| El-Sayed El-Sheikh* 1; Khaled Mahrose2; Ismail Ismail3 | ||||
| 1Plant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. | ||||
| 2Poultry Dept., Fac. Agric., Zagazig University, Zagazig 44511, Egypt | ||||
| 3Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig | ||||
| Abstract | ||||
| The current study aimed to investigate the adverse effects of methomyl (Met) dose at different time intervals alone or with weekly Vitamin E+Selenium (ESe) injection on growth performance, blood biochemical parameters, and liver & kidney histopathological changes of New Zealand White (NZW) growing male rabbits. Five groups of 10 weaned rabbits (at 7 weeks of age and average initial live body weight of 824.40±71.0 g)were randomly assignedand used. The first group was served as control, the 2nd and 3rdgroups were received a daily dose of 10 and 20 mg kg−1 body weight (BW) of Met, while, the 4th and 5thgroups were received a daily dose of 10 and 20.0 mg kg−1 BW of Met with weekly subcutaneously ESe injection. Results of the present study showed that: growth performance did not change significantly throughout experimental periods. Continuous exposure to Met alone or with ESe injection at 28 days showed a significant (P≤0.05 and 0.01) decrease in RBCs count. WBCs was increased significantly (P≤0.01) with exposure to Met only at 35 days. A significant decrease in total protein, urea, aspartate aminotransferase (AST) and alkaline phosphatase (ALP) due to exposure to Met was obtained. However, Alanine aminotrans ferase(ALT) and creatinine were increased significantly at 14 and 35 days. Degenerative changes and edematous fluid in the portal area with necrotic changes in hepatic cells were observed due to Met effect. However, a few of proliferation of bile duct with edematous fluid in the portal area were affected of Met dose with ESe injection. Kidney damage due to Met exposure was involve ingrenal tissue damage with leukocyte infiltration, and degenerative changes due to Met exposure and ESe injection. Dietary Met administration with or without injection of ESe did not significantly affect most of carcass traits studied, except for heart, spleen, lung and fore limb percentages, which were significantly (P≤0.05) differed. In conclusion, the overall findings showed that Met exposure can cause biochemical changes, hepatic and renal damage to rabbits with low protection role of ESein NZW growing male rabbits. | ||||
| Keywords | ||||
| Rabbits; Methomyl; Growth performance; blood parameters; histopathology; carcass traits; vitamin E plus selenium | ||||
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