Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients
Othman, A., Abo El-Atta, H., Gad El-Hak, S., Ghanem, A. (2018). Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients. EKB Journal Management System, 26(2), 17-25. doi: 10.21608/mjfmct.2018.46820
Alyaa A Othman; Hend M Abo El-Atta; Seham Gad El-Hak; Abdel Aziz Ghanem. "Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients". EKB Journal Management System, 26, 2, 2018, 17-25. doi: 10.21608/mjfmct.2018.46820
Othman, A., Abo El-Atta, H., Gad El-Hak, S., Ghanem, A. (2018). 'Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients', EKB Journal Management System, 26(2), pp. 17-25. doi: 10.21608/mjfmct.2018.46820
Othman, A., Abo El-Atta, H., Gad El-Hak, S., Ghanem, A. Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients. EKB Journal Management System, 2018; 26(2): 17-25. doi: 10.21608/mjfmct.2018.46820

Cholinesterase Enzymes as Predictors for Severity Among Acutely Organophosphorus Intoxicated Patients

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Article 2, Volume 26, Issue 2, July 2018, Page 17-25  XML PDF (349.46 K)
Document Type: Original Article
DOI: 10.21608/mjfmct.2018.46820
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Authors
Alyaa A Othman* 1; Hend M Abo El-Attaorcid 1; Seham Gad El-Hak2; Abdel Aziz Ghanem2
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University.
2Forensic Med. & Clin. Toxicology, Mansoura Faculty of Medicine
Abstract
Organophosphorus pesticides are considered a major human health concern, primarily in developing countries. Acute toxicity of these compounds is known to have serious health consequences. The study aimed to assess the role of cholinesterase enzymes (acetylcholinesterase and butyrylcholinesterase) as predictors for severity following acute OP intoxication immediately after admission, using Peradeniya Organophosphorus Poisoning (POP) clinical severity scoring. It was conducted on fifty patients recruited from Mansoura University Emergency Hospital with history of acute exposure to organophosphorus compounds (OPCs). Detection of OP toxicity was done using thin layer chromatography (TLC) technique; assessment of severity of OP poisoning was done using Peradeniya Organophosphorus Poisoning (POP) scale; and estimating ACHE and BuCHE levels that was done using microlab auto-analyzer. No statistically significant associations were found between initial ACHE enzyme levels and POP severity scoring (p=0.075), meanwhile, initial BuCHE levels were significantly associated with POP severity scoring (p=0.045). Thus, measurement of BuCHE enzyme on admission is a sensitive biomarker for acute OP exposure and severity. Although ACHE enzyme is considered a specific biomarker for diagnosis of OP toxicity, it cannot be considered a sensitive biomarker for severity.
Keywords
Organophosphorus; Predictor; Cholinesterase; severity; toxicity; POP
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