IMMUNOHISTOCHEMICAL EXPRESSION OF CD10 AND HER-2/NEU IN UROTHELIAL CARCINOMA VERSUS CHRONIC CYSTITIS IN ZAGAZIG UNIVERSITY HOSPITALS(RETROSPECTIVE STUDY) | ||||
| Zagazig University Medical Journal | ||||
| Article 1, Volume 23, Issue 2, March 2017, Page 1-8 PDF (1.54 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2017.4683 | ||||
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| Authors | ||||
| Asmaa Mohamed; Mohamed Ramadan; Osama Helmy; Samah Mohamed | ||||
| Department of Pathology, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Urinary bladder tumor is the seventh most common worldwide tumor . According to National Cancer Institute in Egypt , urinary bladder tumor constitutes 30% of all cancer cases with an incidence rate of 13.5/100,000 individuals. CD10 protein has been an immediate part in pathways of transduction that control cellular development , apoptosis , metastatic possibilities of cancer cells and influence on invasion .CD10 has prognostic incentive in bladder cancer. HER2/neu protein seems to assume a part in neoplastic cell and included in pathogenesis of urinary bladder carcinoma. Association of HER2 receptor in proliferation of invasive urothelial carcinomas has incited trials to HER2/neu targeted therapies in advanced diseases. Aim of work: To evaluate the immunohistochemical expression of CD10 and HER2/ neu with the pathological parameters of urothelial carcinoma of urinary bladder well as grade and stage versus chronic cystitis Methods: CD10 and HER2/neu expressions were retrospectively analysed by immunohistochemistry in 30 cases of chronic cystitis and 30 paraffin-embedded specimens of patients with primary urothelial carcinoma (UC).The expressions were related to clinicopathological parameters ,well as grade and pathological stage Results: The immunohistochemial expression of CD10 and HER2/neu were negative(score 0) in chronic cystitis cases than urothelial carcinoma and was significantly (p < 0.05). Nineteen cases (63%) of primary urothelial carcinomas were positive for CD10 expression and 17 cases (56.7%) were positive for HER2/neu compared to chronic cystitis . The high grade of urothelial carcinoma and the high pathological stage were significantly connected with the high CD10 and HER2/neu expression (p < 0.05). Conclusion : High CD10 and HER2/neu expression was related to high grade and pathological stage of urothelial carcinoma. | ||||
| Keywords | ||||
| CD10 – HER2/neu – urothelial carcinoma of urinary bladder – Immunohistochemistry (IHC) | ||||
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