EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.
Said, N., Mangoud1, A., Mostafa, S., Yehia, M., Abd El-Aziz, H. (2017). EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.. EKB Journal Management System, 23(2), 1-10. doi: 10.21608/zumj.2017.4685
Nelly Said; Amal Mangoud1; Salah Mostafa; Mohamed Yehia; Hesham Abd El-Aziz. "EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.". EKB Journal Management System, 23, 2, 2017, 1-10. doi: 10.21608/zumj.2017.4685
Said, N., Mangoud1, A., Mostafa, S., Yehia, M., Abd El-Aziz, H. (2017). 'EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.', EKB Journal Management System, 23(2), pp. 1-10. doi: 10.21608/zumj.2017.4685
Said, N., Mangoud1, A., Mostafa, S., Yehia, M., Abd El-Aziz, H. EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.. EKB Journal Management System, 2017; 23(2): 1-10. doi: 10.21608/zumj.2017.4685

EXPRESSION OF LGR5 AND BETA-CATENIN IN BENIGN AND MALIGNANT COLORECTAL LESIONS IN ZAGAZIG UNIVERSITY HOSPITAL.

Zagazig University Medical Journal
Article 3, Volume 23, Issue 2, March 2017, Page 1-10  XML PDF (1.45 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2017.4685
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Authors
Nelly Said1; Amal Mangoud12; Salah Mostafa3; Mohamed Yehia4; Hesham Abd El-Aziz5
1Pathology ,Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt,
2Pathology , Faculty of Medicine, Zagazig University, Zagazig,44519, Egypt,
3Pathology,Faculty of Medicine, Zagazig University, Zagazig,44519, Egypt,
4General surgery departments,Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt,
5Pathology ,Faculty of Medicine, Zagazig University, Zagazig,44519, Egypt,
Abstract
Background: Lgr5 -(GPR49) a Wnt target gene- is one of the most important cancer stem cell markers that have been isolated in colorectal cancer (CRC). The potentiation of Wnt/Beta-catenin signaling is now believed to mediate the self-renewal and proliferation of Lgr5 stem cells. Aim: to evaluate the expression of Lgr5 and Beta-catenin in colorectal cancer and benign colorectal lesions.
Methods: Representative sections from thirty benign lesions [22 colorectal adenomas, 8 ulcerative colitis (UC)], and 30 CRC cases were stained by immunohistochemical technique using anti-Lgr5 and anti-Beta-catenin.
Results: High Lgr5 expression was found in 0%, 60%, and 70% of normal mucosa, benign lesions, and CRC, respectively. Higher grades of Beta-catenin expression compared to normal expression was found in benign lesions as 23.3% for grade II and 6.7% for grade III and in CRC as 73.3% for grade II and 20% for grade III. Significant statistical differences between control groups, benign and malignant lesions in both Lgr5 and Beta-catenin expression were found. Conclusion: Lgr5 is highly expressed in CRC. That may suggest a role in carcinogenesis based on the CSC hypothesis. Also, Beta-catenin is activated in most CRC.
Keywords
Cancer stem cell; Lgr5; Beta-catenin; CRC
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