In vitro Study of Novel Organic/ Inorganic Composite Scaffold for Bone Regeneration
Tohamy, K., Soliman, I., Mabrouk, M., Aboelnasr, M. (2017). In vitro Study of Novel Organic/ Inorganic Composite Scaffold for Bone Regeneration. EKB Journal Management System, 18(1), 1-12. doi: 10.21608/ejbbe.2017.2183.1008
Khairy M. Tohamy; Islam Soliman; Mostafa Mabrouk; Mohamed Aboelnasr. "In vitro Study of Novel Organic/ Inorganic Composite Scaffold for Bone Regeneration". EKB Journal Management System, 18, 1, 2017, 1-12. doi: 10.21608/ejbbe.2017.2183.1008
Tohamy, K., Soliman, I., Mabrouk, M., Aboelnasr, M. (2017). 'In vitro Study of Novel Organic/ Inorganic Composite Scaffold for Bone Regeneration', EKB Journal Management System, 18(1), pp. 1-12. doi: 10.21608/ejbbe.2017.2183.1008
Tohamy, K., Soliman, I., Mabrouk, M., Aboelnasr, M. In vitro Study of Novel Organic/ Inorganic Composite Scaffold for Bone Regeneration. EKB Journal Management System, 2017; 18(1): 1-12. doi: 10.21608/ejbbe.2017.2183.1008

In vitro Study of Novel Organic/ Inorganic Composite Scaffold for Bone Regeneration

Egyptian Journal of Biomedical Engineering and Biophysics
Article 1, Volume 18, Issue 1, 2017, Page 1-12  XML PDF (2.59 MB)
Document Type: Original Article
DOI: 10.21608/ejbbe.2017.2183.1008
View on SCiNiTO View on SCiNiTO
Authors
Khairy M. Tohamyorcid 1; Islam Soliman email orcid 2; Mostafa Mabrouk3; Mohamed Aboelnasrorcid 4
1physics department,Faculty of Science, Al-Azhar University, Cairo, Egypt
2Department of physics, faculty of Science, Al Azhar University, Cairo, Egypt.
3Refractories, Ceramics and Building materials Department, (Biomaterials group), National Research Centre, 33El Bohouth st.(former EL Tahrir st.)- Dokki- Giza- Egypt
4physics department, faculty of science , al azhar university, Cairo, Egypt
Abstract
In this study, polysaccharide polymers /Hydroxyapatite composite scaffolds were prepared by using freeze-drier processing technique. The microstructure and morphology as well as mechanical strength of the scaffolds were characterized by XRD, FTIR, SEM, EDX, and other methods. The porosity ratio and in vitro biomineralization of the scaffold were also evaluated. It was found that, both porosity and compressive strength are strongly dependent on the concentration of HA. The porosity was reduced from ≈ 87 ±5.1% to 66.7±3.2%, while the mechanical measurements revealed that, the compressive strength reaches the highest value 23.96±0.82 MPa by adding HA to hybrid polymers. In addition, Blended hydroxyethylcellulose to sodium alginate cause increase of total pore volume inside scaffold, decrease in mechanical properties and the presence of bioceramic inside scaffolds structure enhances the precipitation and biomineralization of HA from SBF on scaffolds surface. Thus results suggest that these biocompatible composite scaffolds can be useful for bone tissue regeneration.
Keywords
Polysaccharide; Hydroxyapatite; Alginates; SBF
Statistics
Article View: 1,749
PDF Download: 546