Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate
Adree, H., Aldabah, F., Abo Baraka, W., Alshazly, S. (2018). Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate. EKB Journal Management System, 26(2), 155-167. doi: 10.21608/mjfmct.2018.47200
Hamada Adree; Fouad H Aldabah; Waleed E Abo Baraka; Sherief M Alshazly. "Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate". EKB Journal Management System, 26, 2, 2018, 155-167. doi: 10.21608/mjfmct.2018.47200
Adree, H., Aldabah, F., Abo Baraka, W., Alshazly, S. (2018). 'Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate', EKB Journal Management System, 26(2), pp. 155-167. doi: 10.21608/mjfmct.2018.47200
Adree, H., Aldabah, F., Abo Baraka, W., Alshazly, S. Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate. EKB Journal Management System, 2018; 26(2): 155-167. doi: 10.21608/mjfmct.2018.47200

Incidence and Factors Influencing Acute Tramadol Toxicity-Inducing Seizures in Damietta Governorate

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Article 12, Volume 26, Issue 2, July 2018, Page 155-167  XML PDF (400.66 K)
Document Type: Original Article
DOI: 10.21608/mjfmct.2018.47200
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Authors
Hamada Adree email orcid 1; Fouad H Aldabah2; Waleed E Abo Baraka1; Sherief M Alshazly3
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Al-Azhar University (New Damietta)
2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Al-Azhar University (Cairo)
3Department of Neurology, Faculty of Medicine, Al-Azhar University (New Damietta).
Abstract
An increased rate of seizures due to tramadol poisoning has been observed. However, the actual incidence and related factors are not well-studied. The purpose of this work was to investigate the relationship between the incidence of seizures and plasma tramadol level in patients with tramadol-inducing seizures. In addition, we reported the pattern of tramadol overdoses in selected patients. The study was conducted from 1st January 2017 to 28th February 2018. It involved 102 cases who recruited from toxicological units of AlAzhar University Hospital (New Damietta). After free informed consent to contribute in this study and within one hour after arrival to a toxicological unit, 10 mL of blood were separated and the serum was used for extraction of tramadol residues by using a highperformance liquid chromatography (HPLC) and other blood samples were stored at _ 8oC for the following assays to all patients; fasting blood sugar, hemoglobin levels, serum urea, serum creatinine and liver enzymes. Then clinical examination to all patients included vital signs with a special attention to central nervous system (CNS) manifestations, gastrointestinal (GIT) manifestation. The frequency of seizures (27.4%) with acute tramadol poisoning in humans is not dose dependent and seizures occurred with therapeutic doses and there were no relation between blood tramadol level and seizures. We concluded that risk of seizures increase in cases took other drugs with tramadol as alcohol and heroin. The frequency of seizures is not dose dependent; seizures occurred with therapeutic doses.
Keywords
tramadol; HPLC; Seizures; detection
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