Repeated Tramadol Administration Induced Bleeding in Albino Rats
Roshdy, H., Abdel-Rahman, R., Azzam, H., El-Bakary, A. (2018). Repeated Tramadol Administration Induced Bleeding in Albino Rats. EKB Journal Management System, 26(2), 169-177. doi: 10.21608/mjfmct.2018.47201
Hanem M Roshdy; Rania Hamed Abdel-Rahman; Hanan Azzam; Amal A. El-Bakary. "Repeated Tramadol Administration Induced Bleeding in Albino Rats". EKB Journal Management System, 26, 2, 2018, 169-177. doi: 10.21608/mjfmct.2018.47201
Roshdy, H., Abdel-Rahman, R., Azzam, H., El-Bakary, A. (2018). 'Repeated Tramadol Administration Induced Bleeding in Albino Rats', EKB Journal Management System, 26(2), pp. 169-177. doi: 10.21608/mjfmct.2018.47201
Roshdy, H., Abdel-Rahman, R., Azzam, H., El-Bakary, A. Repeated Tramadol Administration Induced Bleeding in Albino Rats. EKB Journal Management System, 2018; 26(2): 169-177. doi: 10.21608/mjfmct.2018.47201

Repeated Tramadol Administration Induced Bleeding in Albino Rats

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Article 13, Volume 26, Issue 2, July 2018, Page 169-177  XML PDF (375.57 K)
Document Type: Original Article
DOI: 10.21608/mjfmct.2018.47201
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Authors
Hanem M Roshdy email 1; Rania Hamed Abdel-Rahman2; Hanan Azzam3; Amal A. El-Bakaryorcid 4
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University.
2Forensic Medicine & Clinical Toxicology, Mansoura University
3Clinical Pathology Department, Mansoura University.
4Forensic Med. & Clin. Toxicology, Mansoura Faculty of Medicine, Egypt
Abstract
Tramadol abuse is a major health problem. Its effects on hemostasis showed controversial findings. The aim of the present study was to investigate the subchronic toxic effects of tramadol on some hemostatic parameters in Wistar albino rats. Before performance of the study, bleeding time, prothrombin time (PT), activated partial thromboplastin time (APTT) as well as Adenosine Diphosphate (ADP) induced platelet aggregation percentage were measured to get reference values for normal levels. Rats were then given tramadol by gavage in a dose of 20 mg/kg once daily for six weeks and the previously mentioned haematological parameters were measured at two, four and six weeks. The results reveal that tramadol enhanced bleeding tendency along the six weeks of the study as evidenced by prolonged bleeding time, PT, APTT, and decreased ADPinduced platelet aggregation. It can be concluded that tramadol could affect hemostatic parameters in favour of bleeding tendency. Further studies are warranted to confirm these effects and to investigate the possible underlying mechanisms and the potential reversibility of toxicity after drug abstinence.
Keywords
tramadol; Bleeding; PT; APTT; Platelet aggregation; albino rats
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