The possible Protective role of alpha-lipoic acid on nanosilver particle-induced hepatotoxicity in male rats
M. Abd Elmaksoud, E., M.Taha, N., A. Lebda, M., A. Kamel, M. (2019). The possible Protective role of alpha-lipoic acid on nanosilver particle-induced hepatotoxicity in male rats. EKB Journal Management System, 15(1), 85-97. doi: 10.21608/blj.2019.47569
Eman M. Abd Elmaksoud; Nabil M.Taha; Mohamed A. Lebda; Maher A. Kamel. "The possible Protective role of alpha-lipoic acid on nanosilver particle-induced hepatotoxicity in male rats". EKB Journal Management System, 15, 1, 2019, 85-97. doi: 10.21608/blj.2019.47569
M. Abd Elmaksoud, E., M.Taha, N., A. Lebda, M., A. Kamel, M. (2019). 'The possible Protective role of alpha-lipoic acid on nanosilver particle-induced hepatotoxicity in male rats', EKB Journal Management System, 15(1), pp. 85-97. doi: 10.21608/blj.2019.47569
M. Abd Elmaksoud, E., M.Taha, N., A. Lebda, M., A. Kamel, M. The possible Protective role of alpha-lipoic acid on nanosilver particle-induced hepatotoxicity in male rats. EKB Journal Management System, 2019; 15(1): 85-97. doi: 10.21608/blj.2019.47569

The possible Protective role of alpha-lipoic acid on nanosilver particle-induced hepatotoxicity in male rats

Biochemistry Letters
Article 7, Volume 15, Issue 1, 2019, Page 85-97  XML PDF (739.39 K)
Document Type: Original Article
DOI: 10.21608/blj.2019.47569
View on SCiNiTO View on SCiNiTO
Authors
Eman M. Abd Elmaksoud1; Nabil M.Taha1; Mohamed A. Lebda1; Maher A. Kamel2
1Department of Biochemistry, Faculty of Veterinary medicine, Alexandria University, Egypt.
2Department of Biochemistry, Medical Research Institute, Alexandria University, Egypt.
Abstract
Objective: This study aimed to explore the hepatotoxicity induced by silver nanoparticles (AgNPs) and to assess the hepatoprotective effects of α-lipoic acid (LA) against this toxicity. Methods: Thirty adult male rats were enrolled into 3 equal groups; Control, AgNPs (50 mg/kg/i.P) and LA (100 mg/kg/orally) +AgNPs. After 30 days, blood and liver tissues were collected for further studies. Results: AgNPs exposure enhanced lipid peroxidation(+281.7%) along with declines in glutathione (−58.3%) Level in hepatic tissues. The apparent hepatic oxidative damage was associated with obvious hepatic dysfunction that was ascertained by hepatopathological lesions.As, following AgNPs exposure, hepatic silver content and serum ALT, AST and ALP activities were increased, moreover allows calcium influx and induces intracellular calcium overload. Hepatic tissues treated with AgNPs showed down-regulation of all the genes considered (PGC-1α, Tfam and Nrf2).LA improved the serious effects of AgNPs on the liver tissues through its antioxidant andmetal chelator efficacy. Conclusion: Silver nanoparticles (AgNPs) can induce hepatotoxicity along with oxidative stress, substantial decrease in cell viability with concomitant increases in DNA damage. Oral treatment with LA effectively counteracted the adverse effects of AgNPs. 
Keywords
silver nanoparticles; α-Lipoic acid; Hepatotoxicity; Oxidative Stress; Mitocondrial dysfunction
Statistics
Article View: 328
PDF Download: 379