Synthesis of Nano Sulfur particles and their Antitumor activity
Z. Mohammed, F., Hammad, M., AL-dulaimi, M. (2018). Synthesis of Nano Sulfur particles and their Antitumor activity. EKB Journal Management System, 14(1), 109-128. doi: 10.21608/blj.2018.47589
Faten Z. Mohammed; Mustafa Hammad; Muayad AL-dulaimi. "Synthesis of Nano Sulfur particles and their Antitumor activity". EKB Journal Management System, 14, 1, 2018, 109-128. doi: 10.21608/blj.2018.47589
Z. Mohammed, F., Hammad, M., AL-dulaimi, M. (2018). 'Synthesis of Nano Sulfur particles and their Antitumor activity', EKB Journal Management System, 14(1), pp. 109-128. doi: 10.21608/blj.2018.47589
Z. Mohammed, F., Hammad, M., AL-dulaimi, M. Synthesis of Nano Sulfur particles and their Antitumor activity. EKB Journal Management System, 2018; 14(1): 109-128. doi: 10.21608/blj.2018.47589

Synthesis of Nano Sulfur particles and their Antitumor activity

Biochemistry Letters
Article 9, Volume 14, Issue 1, 2018, Page 109-128  XML PDF (1.51 MB)
Document Type: Original Article
DOI: 10.21608/blj.2018.47589
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Authors
Faten Z. Mohammed1; Mustafa Hammad2; Muayad AL-dulaimi1
1Chemistry department (Biochemistry Division), Faculty of Science, Zagazig University, Egypt
2Chemistry department,Faculty of Education for pure Sciences, Diyala,University,Baghdad, Iraq
Abstract
 




 Objectives: Sulphur is among the most common minerals in the body mainly in proteins, but, also, commonly found in tissues joints and cells .At the same time there is a rapidly expanding literature on the effects, of sulphur in regulating biologicaly systems. Methods: Preparation of sulfur nanoparticles (S-NPs) was preparation and fabrication of nanosulfar were performed. Firstly, the evaluation of their composition and purity by fourier transform infrared spectrometer (FT-IR) analysis. Secondly, The shape and size of S-NPs were investigated by scanning electron microscopy (SEM) techniques in all S-NPs samples were size 50nm, 10nm and 5 nm , Then, Energy-dispersive X-ray spectroscopy (EDS) for the evaluation of their composition and purity, after that the X-Ray diffraction, and the determination of S-NPs antitumor activity against (MCF-7, HepG2, HCT116, and PC3) cell lines and were minimum inhibitory concentrations found to be 10.7 ng/ml, 3.7 ng/ml ,10.6ng/ml, and 3.34 ng/ml; respectively. Finaly, determination biochemical assay of S-NPs by using female mice bearing EAC and of the assessment of liver functions, kidney functions, heart functions and hematology markers. Results: This study revealed that S-NPs showed high strong activities in concentration (5 mg/kg) as it improvement of liver functions production compared to the positive control group, also showed the effect of S-NPs of the kidney functions , heart functions and hematology parameters in all studied groups and a significant increase in activities compared with positive control group. 
Keywords
sulfur nanoparticles; toxicity; Ehrlich Ascites Carcinoma; Viable cell count; hematological
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