The ameliorative effect of Naringenin and Hesperidin on Iron oxide Nanoparicles toxicity
M.A.Hussein, M., H. Soliman, A., M.Ahmed, M., I. khater, S., A. El-sayed, A. (2018). The ameliorative effect of Naringenin and Hesperidin on Iron oxide Nanoparicles toxicity. EKB Journal Management System, 14(1), 109-128. doi: 10.21608/blj.2018.47590
Mohamed M.A.Hussein; Aida H. Soliman; Mona M.Ahmed; Safaa I. khater; Abeer A. El-sayed. "The ameliorative effect of Naringenin and Hesperidin on Iron oxide Nanoparicles toxicity". EKB Journal Management System, 14, 1, 2018, 109-128. doi: 10.21608/blj.2018.47590
M.A.Hussein, M., H. Soliman, A., M.Ahmed, M., I. khater, S., A. El-sayed, A. (2018). 'The ameliorative effect of Naringenin and Hesperidin on Iron oxide Nanoparicles toxicity', EKB Journal Management System, 14(1), pp. 109-128. doi: 10.21608/blj.2018.47590
M.A.Hussein, M., H. Soliman, A., M.Ahmed, M., I. khater, S., A. El-sayed, A. The ameliorative effect of Naringenin and Hesperidin on Iron oxide Nanoparicles toxicity. EKB Journal Management System, 2018; 14(1): 109-128. doi: 10.21608/blj.2018.47590

The ameliorative effect of Naringenin and Hesperidin on Iron oxide Nanoparicles toxicity

Biochemistry Letters
Article 10, Volume 14, Issue 1, 2018, Page 109-128  XML
Document Type: Original Article
DOI: 10.21608/blj.2018.47590
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Authors
Mohamed M.A.Hussein1; Aida H. Soliman2; Mona M.Ahmed3; Safaa I. khater1; Abeer A. El-sayed2
1Department of Biochemistry, Faculty of veterinary Medicine, Zagazig University, Egypt
2Department of chemistry, Faculty of Science, Suez Canal University, Egypt
3Department of Forensic science and toxicology,Faculty of Veterinary Medicine, Zagazig University, Egypt
Abstract
 




 Objectives: Sulphur is among the most common minerals in the body mainly in proteins, but, also, commonly found in tissues joints and cells .At the same time there is a rapidly expanding literature on the effects, of sulphur in regulating biologicaly systems. Methods: Preparation of sulfur nanoparticles (S-NPs) was preparation and fabrication of nanosulfar were performed. Firstly, the evaluation of their composition and purity by fourier transform infrared spectrometer (FT-IR) analysis. Secondly, The shape and size of S-NPs were investigated by scanning electron microscopy (SEM) techniques in all S-NPs samples were size 50nm, 10nm and 5 nm , Then, Energy-dispersive X-ray spectroscopy (EDS) for the evaluation of their composition and purity, after that the X-Ray diffraction, and the determination of S-NPs antitumor activity against (MCF-7, HepG2, HCT116, and PC3) cell lines and were minimum inhibitory concentrations found to be 10.7 ng/ml, 3.7 ng/ml ,10.6ng/ml, and 3.34 ng/ml; respectively. Finaly, determination biochemical assay of S-NPs by using female mice bearing EAC and of the assessment of liver functions, kidney functions, heart functions and hematology markers. Results: This study revealed that S-NPs showed high strong activities in concentration (5 mg/kg) as it improvement of liver functions production compared to the positive control group, also showed the effect of S-NPs of the kidney functions , heart functions and hematology parameters in all studied groups and a significant increase in activities compared with positive control group. 
Keywords
sulfur nanoparticles; toxicity; Ehrlich Ascites Carcinoma; Viable cell count; hematological
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