Silver Nanoparticles Effect on Cytokines in Rat | ||||
| Biochemistry Letters | ||||
| Article 14, Volume 13, Issue 1, 2017, Page 172-182 PDF (537.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/blj.2017.47608 | ||||
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| Authors | ||||
| I. Ashour1; S, Saleh1; A. , Shalhy1; E. Ibrahim2; M., Doiwdar2 | ||||
| 1Biochemistry Department, Faculty of Vet. Medicine , Suez Canal University, Egypt | ||||
| 2Animal Health Research Institute , Agriculture Research centre, Dokki , Egypt | ||||
| Abstract | ||||
| Background: Silver nanoparticles (AgNPs) was recommended in medicine and veterinary medicine fields, and can be used as drugs for treatment of some diseases. Aim: the toxicity of nanosilver is not well known, it is essential to examine its safety. The experimental albino rats were divided into five groups , each group comprising of ten rats, after adaptation in the animal houses in Faulty of Vet. Medicine Suez Cana University for one week. The groups named as N1, 2, 3, 4 and 5. Group N1, was called control group and was gives deionized water. Blood samples were collected at the end of experiment; serum samples were separated for determination the values of IL-Lβ, IL-2, IL-6, IL-10 and TNF-α. Ag-NPs administration showed a variable significant increase in the levels of Il-Lβ, IL-2, IL-6, IL10 and TNF- α . Conclusion : Nanoparticles induce inflammatory immune responses at lower concentrations and chemokines are the major cytokines induced at early stage of exposure to silver nanoparticles.. | ||||
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