Does maternal serum insulin-like growth factor-I have a role in the prediction of preeclampsia in Egyptian women?
Seleem, A., Abdel Aziz, A., Abdelfatah, H., El-Gharib, M., El-Dahtory, F., Basha, E. (2018). Does maternal serum insulin-like growth factor-I have a role in the prediction of preeclampsia in Egyptian women?. EKB Journal Management System, 14(1), 155-163. doi: 10.21608/blj.2018.47616
Amal K. Seleem; A. A. Abdel Aziz; Hosam Abdelfatah; M. S. A. El-Gharib; Faeza El-Dahtory; Eatimad A. Basha. "Does maternal serum insulin-like growth factor-I have a role in the prediction of preeclampsia in Egyptian women?". EKB Journal Management System, 14, 1, 2018, 155-163. doi: 10.21608/blj.2018.47616
Seleem, A., Abdel Aziz, A., Abdelfatah, H., El-Gharib, M., El-Dahtory, F., Basha, E. (2018). 'Does maternal serum insulin-like growth factor-I have a role in the prediction of preeclampsia in Egyptian women?', EKB Journal Management System, 14(1), pp. 155-163. doi: 10.21608/blj.2018.47616
Seleem, A., Abdel Aziz, A., Abdelfatah, H., El-Gharib, M., El-Dahtory, F., Basha, E. Does maternal serum insulin-like growth factor-I have a role in the prediction of preeclampsia in Egyptian women?. EKB Journal Management System, 2018; 14(1): 155-163. doi: 10.21608/blj.2018.47616

Does maternal serum insulin-like growth factor-I have a role in the prediction of preeclampsia in Egyptian women?

Biochemistry Letters
Article 12, Volume 14, Issue 1, 2018, Page 155-163  XML
Document Type: Original Article
DOI: 10.21608/blj.2018.47616
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Authors
Amal K. Seleem1; A. A. Abdel Aziz2; Hosam Abdelfatah2; M. S. A. El-Gharib3; Faeza El-Dahtory4; Eatimad A. Basha5
1Department of Biochemistry, Faculty of Medicine / Mansoura University, Mansoura, Egypt
2Department of Gynocology, Faculty of Medicine/ Mansoura University, Mansoura, Egypt
3Department of Chemistry, Faculty of Science/ Port Said University, Port Said, Egypt
4Genetic Unit, Children Hospital / Mansoura University, Mansoura, Egypt
5Department of Chemistry, Central laboratories/ Ministry of Health-Damietta, Egypt
Abstract
Background: Preeclampsia is characterized pregnancy-induced hypertension and proteinuria complicates 3 – 4% of pregnancies and thus is a leading cause of maternal and fetal morbidity and mortality. We aimed to assess the circulating IGF-I in the second trimester is associated with subsequent risk of preeclampsia. Subjects and methods: A case-control study included 60 women with preeclampsia and 30 normotensive women as control. All groups were strictly matched for gestational age at second trimester sampling of IGF-I levels, the IGF-I was measured with ELISA. Results: Diagnostic criteria for preeclampsia included blood pressure above 140/90 and proteinuria above 300mg. Mean ages of participants, gestational week, weight and BMI were similar. A decrease in IGF-I at second trimester was associated with higher risk of preeclampsia (P < 0.001). Conclusion: In pregnancies destined to develop PE, decrease of the circulating levels of IGF-I from the second trimester of pregnancy may be implicated in the pathogenesis of the disease. 
Keywords
insulin-like growth factor-I; preeclampsia and pregnancy
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