Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients
Mohamed, F., El-Deen, I., Ismail, D. (2018). Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients. EKB Journal Management System, 14(1), 180-186. doi: 10.21608/blj.2018.47619
Faten Zahran Mohamed; Ibrahim El-Sayed M. El-Deen; Dina Mohamed Mohamed Ismail. "Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients". EKB Journal Management System, 14, 1, 2018, 180-186. doi: 10.21608/blj.2018.47619
Mohamed, F., El-Deen, I., Ismail, D. (2018). 'Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients', EKB Journal Management System, 14(1), pp. 180-186. doi: 10.21608/blj.2018.47619
Mohamed, F., El-Deen, I., Ismail, D. Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients. EKB Journal Management System, 2018; 14(1): 180-186. doi: 10.21608/blj.2018.47619

Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients

Biochemistry Letters
Article 15, Volume 14, Issue 1, 2018, Page 180-186  XML PDF (602.45 K)
Document Type: Original Article
DOI: 10.21608/blj.2018.47619
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Authors
Faten Zahran Mohamed1; Ibrahim El-Sayed M. El-Deen2; Dina Mohamed Mohamed Ismail2
1Chemistry Department , Faculty of Science ,ZagazigUniversity ,Egypt
2Chemistry Department, Faculty of Science, Port Said University, Egypt
Abstract
Liver biopsy is invasive and prone to complications but it stills the gold standard for assessing hepatitis C virus (HCV)-related fibrosis. This study was designed to study non-invasive methods for the assessment of liver fibrosis. Our aim was to validate and compare the performance of MMP-8, upA in addition to GAL-3 as simple blood markers for different stages of liver fibrosis in HCV patients. The study was carried out on 90 individuals divided into the following groups: group 1: normal control, group 2: F1 = portal fibrosis without septa, group 3: F2 = few septa, group 4: F3 = numerous septa without cirrhosis and group 5: F4 = cirrhosis. Our results showed a positive correlation between MMP-8, upA and GAL-3 level and degree of liver fibrosis. We can conclude that, using of MMP-8, upA in addition to GAL-3 as simple biochemical markers for the assessment of hepatic fibrosis as alternative to liver biopsy. 
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