Role of oxidant-Antioxidant Imbalance in the Pathogenesis of Acute Post-Streptococcal Glomerulonephritis
Tawfeek, D., El-Saed, W., Sherif, L., El-Najjar, I., Selim, S., El-Saka, H. (2003). Role of oxidant-Antioxidant Imbalance in the Pathogenesis of Acute Post-Streptococcal Glomerulonephritis. EKB Journal Management System, 3(1), 45-51. doi: 10.21608/geget.2003.47660
Doaa Tawfeek; Wafaa El-Saed; Laila Sherif; Ismail El-Najjar; Samy Selim; Hesham El-Saka. "Role of oxidant-Antioxidant Imbalance in the Pathogenesis of Acute Post-Streptococcal Glomerulonephritis". EKB Journal Management System, 3, 1, 2003, 45-51. doi: 10.21608/geget.2003.47660
Tawfeek, D., El-Saed, W., Sherif, L., El-Najjar, I., Selim, S., El-Saka, H. (2003). 'Role of oxidant-Antioxidant Imbalance in the Pathogenesis of Acute Post-Streptococcal Glomerulonephritis', EKB Journal Management System, 3(1), pp. 45-51. doi: 10.21608/geget.2003.47660
Tawfeek, D., El-Saed, W., Sherif, L., El-Najjar, I., Selim, S., El-Saka, H. Role of oxidant-Antioxidant Imbalance in the Pathogenesis of Acute Post-Streptococcal Glomerulonephritis. EKB Journal Management System, 2003; 3(1): 45-51. doi: 10.21608/geget.2003.47660

Role of oxidant-Antioxidant Imbalance in the Pathogenesis of Acute Post-Streptococcal Glomerulonephritis

GEGET
Article 5, Volume 3, Issue 1, August 2003, Page 45-51  XML PDF (450.64 K)
Document Type: Original Article
DOI: 10.21608/geget.2003.47660
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Authors
Doaa Tawfeek1; Wafaa El-Saed1; Laila Sherif1; Ismail El-Najjar1; Samy Selim2; Hesham El-Saka3
1Departments of paediatrics, Medical Biochemistry, Zagazig University, Zagazig, Egypt.
2Department of Community Medicine, Zagazig University, Zagazig, Egypt.
3Faculty of Medicine and Zagazig University Hospitals, Zagazig University, Zagazig, Egypt.
Abstract
Background: A still-growing body of evidence has accumulated indicating that a disturbance of balance between oxidative stress and antioxidant defense mechanisms plays a major role in the pathomechanism of glomerular diseases.
Objectives: This study was carried out to evaluate the role of oxidant-antioxidant imbalance in the pathogenesis of acute post-streptococcal glomerulonephritis (APSGN).
Methods: Serum levels of some antioxidants (α-tocopherol, superoxide dismutase (SOD), selenium, zinc and copper) were estimated in 50 children, of ages ranging from 2 to 10 years (mean ± SD, 8.1 ± 2.5 years), diagnosed as APSGN, and compared with that of 25 healthy age-and sex-matched control children. Oxidant stress was evaluated as well, in all subjects by estimating levels of serum and urinary malondialdhyde (MDA).
Results: The levels of antioxidants were significantly decreased in children suffering from APSGN compared to control children. Meanwhile oxidative stress, measured by serum and urinary MDA was significantly increased in the patients group. In addition, a significant positive correlation between SOD and both copper and zinc was reported.
Conclusions: An oxidative stress, in the face of defective antioxidant defense, does exist and may play a particular role in the pathogenesis of acute post-streptococcal glomerulonephritis. So it is recommended that nutritional antioxidants, especially vitamin E, selenium, zinc, and copper should be added in the diet of children and all risky groups.   
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