SERUM LACTATE AS A BIOMARKER IN MULTIPLE SCLEROSIS
Ragab, S., Sarhan, A., El Sayed, D., Lotfy, S., Zidan, A. (2021). SERUM LACTATE AS A BIOMARKER IN MULTIPLE SCLEROSIS. EKB Journal Management System, 27(5), 832-838. doi: 10.21608/zumj.2019.14966.1352
Salma Mohamed Ragab; AbdAllah Sarhan; Dorriya El Sayed; Sabah Lotfy; Amal Zidan. "SERUM LACTATE AS A BIOMARKER IN MULTIPLE SCLEROSIS". EKB Journal Management System, 27, 5, 2021, 832-838. doi: 10.21608/zumj.2019.14966.1352
Ragab, S., Sarhan, A., El Sayed, D., Lotfy, S., Zidan, A. (2021). 'SERUM LACTATE AS A BIOMARKER IN MULTIPLE SCLEROSIS', EKB Journal Management System, 27(5), pp. 832-838. doi: 10.21608/zumj.2019.14966.1352
Ragab, S., Sarhan, A., El Sayed, D., Lotfy, S., Zidan, A. SERUM LACTATE AS A BIOMARKER IN MULTIPLE SCLEROSIS. EKB Journal Management System, 2021; 27(5): 832-838. doi: 10.21608/zumj.2019.14966.1352

SERUM LACTATE AS A BIOMARKER IN MULTIPLE SCLEROSIS

Zagazig University Medical Journal
Article 219, Volume 27, Issue 5, September 2021, Page 832-838  XML PDF (409.44 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.14966.1352
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Authors
Salma Mohamed Ragab email 1; AbdAllah Sarhan2; Dorriya El Sayed3; Sabah Lotfy4; Amal Zidan5
1Neurology department, Faculty of medicine, Kafr Elsheikh University , Egypt
2Neurology department Faculty of Medicine – Zagazig University. Egypt
3Neurology department , Faculty of Medicine – Zagazig University. Egypt
4Neurology department , Faculty of medicine , Zagazig University , Egypt
5Clinical Patholgy department, Faculty of Medicine – Zagazig University Egypt.
Abstract
Abstract
Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system with secondary progressive neurodegenerative changes lead to accumulation of disability. The important role of mitochondrial dysfunction has been reported in the pathogenesis of MS.
Objective: To investigate the serum lactate level in MS and to explore the prognostic value of lactate regarding disability and progression
Methods: This case-control study was conducted on 80 Egyptian subjects; 40 MS patients and 40 normal healthy individuals. Patients were subjected to detailed history taking, thorough neurological examination and clinical assessment of the disability using Expanded Disability Status Scale (EDSS(.Serum level of lactate was measured in both groups.
Results: In comparison to control, serum lactate level was significantly higher among MS patients. There was no significant correlation between serum lactate level and any clinical variants apart from age and age of onset of MS.
Conclusion: Measurement of serum lactate may be helpful in MS and this support the hypothesis of the critical role of mitochondrial dysfunction and axonal damage in MS. Our study recommend future researches on large cohort of MS patients to assess long term prognosis in patients with elevated lactate levels .In addition , we recommend measurement of lactate in cerebrospinal fluid of MS patients to evaluate its clinical significance as a biomarker in MS..
Keywords
Multiple sclerosis; Lactate; EDSS; Mitochondrial dysfunction
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