Immunotoxicity of Some Pesticides in Egyptian Diabetic Children
Abdel-Rahman, R., El Morsi, D., Abd El- Aziz, S., El-Sharkawy, A. (2012). Immunotoxicity of Some Pesticides in Egyptian Diabetic Children. EKB Journal Management System, 20(2), 1-15. doi: 10.21608/mjfmct.2012.47724
Rania Hamed Abdel-Rahman; Doaa A. El Morsi; Sherin M Abd El- Aziz; Ashraf A. El-Sharkawy. "Immunotoxicity of Some Pesticides in Egyptian Diabetic Children". EKB Journal Management System, 20, 2, 2012, 1-15. doi: 10.21608/mjfmct.2012.47724
Abdel-Rahman, R., El Morsi, D., Abd El- Aziz, S., El-Sharkawy, A. (2012). 'Immunotoxicity of Some Pesticides in Egyptian Diabetic Children', EKB Journal Management System, 20(2), pp. 1-15. doi: 10.21608/mjfmct.2012.47724
Abdel-Rahman, R., El Morsi, D., Abd El- Aziz, S., El-Sharkawy, A. Immunotoxicity of Some Pesticides in Egyptian Diabetic Children. EKB Journal Management System, 2012; 20(2): 1-15. doi: 10.21608/mjfmct.2012.47724

Immunotoxicity of Some Pesticides in Egyptian Diabetic Children

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Article 1, Volume 20, Issue 2, July 2012, Page 1-15  XML PDF (38.78 MB)
Document Type: Original Article
DOI: 10.21608/mjfmct.2012.47724
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Authors
Rania Hamed Abdel-Rahman1; Doaa A. El Morsiorcid 2; Sherin M Abd El- Aziz3; Ashraf A. El-Sharkawy4
1Forensic Medicine & Clinical Toxicology, Mansoura University, Egypt
2Department of Forensic Medicine and Clinical Toxicology; Faculty of Medicine, Mansoura University, Egypt
3Department of Clinical Pathology; Faculty of Medicine, Mansoura University, Egypt.
4Mansoura University Children Hospital, Faculty of Medicine, Mansoura University, Egypt.
Abstract
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disorder that could be triggered by environmental pollutants in genetically susceptible individuals. The present study aimed to assess the immune response of different lymphocyte subpopulations in a group of diabetic children in relation to pesticides with highest Odds ratios (lindane and malathion).  One hundred and ten Egyptian children; their ages ranged from 1.2 to 10 years were studied. The control group comprised 35 healthy children, while the study group included 75 children (diagnosed as T1DM within the first month). Seven whole peripheral blood sample was collected from each child and was divided as follows: 5 ml blood was taken for toxicological analysis of pesticides residues using Gas Chromatography equipped with Ni63 Electron Capture Detector. The remaining 2 ml blood sample was collected in EDTA tubes and used immediately for testing immunological markers by using flowcytometry. The results revealed significant correlation as regards the expression of CD4 %, HLADR % and CD4/CD8 ratio in relation to lindane. While malathion (an organophosphate compound), shows a significant correlation with CD4 %, CD20 %, CD16 % and HLDAR % lymphocyte subsets in the diabetic group compared to healthy subjects. It is concluded that pesticides might play a role concerning the increased incidence of T1DM in children. 
Keywords
Pesticides; Childhood Diabetes; Immunotoxicity
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