Circulating Kidney Injury Molecule-1 (Kim-1) As an Early Predictor of Chronic Gasoline Exposure-Induced Nephrotoxicity in Minia City, Minia, Egypt | ||||
| Mansoura Journal of Forensic Medicine and Clinical Toxicology | ||||
| Article 6, Volume 24, Issue 2, July 2016, Page 81-95 PDF (39.62 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjfmct.2016.47926 | ||||
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| Authors | ||||
| Mohamed A.M. Khalaf; Ahmad Hefnawy; Mostafa Abulhamad | ||||
| Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine- Minia University | ||||
| Abstract | ||||
| Long-term exposure to gasoline had been proved to induce nephrotoxicity among gasoline handlers. This study evaluated the efficiency of using circulating kidney injury molecule 1 (KIM-1) as an early predictor of nephrotoxic effect of long-term occupational exposure to gasoline in Minia city. Eighty three male subjects were involved and were divided into 4 groups: group I: 20 apparently healthy subjects with no history of long-term gasoline exposure, group II: 19 gas station workers for a period of 1 years ± 2 months, group III: 27 gas station workers for a period of 3 years ± 2 months, and group IV: 17 gas station workers for a period of 5 years ± 2 months. All subjects were investigated for blood urea nitrogen (BUN), serum creatinine (S.Cr.) and KIM-1. The levels BUN and S.Cr. of the subjects of group III were within normal with no significant differences when compared to those of groups I and II while the level of KIM-1 was significantly increased when compared to groups I and II. The levels BUN, S.Cr. and KIM-1 of group IV subjects were significantly elevated when compared to other groups. Also, there was a positive correlation of the level of S.Cr. to the levels of KIM-1 among group IV. It is important to use protective measures at these stations, and to develop a more safe fuel in the near future as long-term exposure to gasoline may carry the risk of nephrotoxicity. KIM-1 may be a promising early predictor of such nephrotoxic effects. | ||||
| Keywords | ||||
| Nephrotoxicity; gasoline; gas stations; blood urea nitrogen; serum creatinine; kidney injury molecule 1 (KIM-1) | ||||
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