Biochemical alterations associated with experimentally induced breast cancer in rats | ||||
Damanhour Journal of Veterinary Sciences | ||||
Article 3, Volume 1, Issue 2, 2019, Page 11-13 PDF (564.02 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/DJVS.32001 | ||||
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Authors | ||||
Mohamed Zewail1; Nabil Taha2; Kadry Sadek 1; Yasser El-Sayed3; Sherif Nasr4 | ||||
1Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Egypt | ||||
2Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt | ||||
3Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Egypt | ||||
4Department of Animal Husbandry and Wealth Development, Faculty of Veterinary Medicine, Damanhour University, Egypt | ||||
Abstract | ||||
This study was conducted to demonstrate the preventive graviola effect on breast cancer induced by 7,12-dimethylbenz [a] anthracene (DMBA) in fifty female rats distributed into four groups. Group I: Control group injected orally by physiological saline, group II: DMBA induced-breast cancer, injected orally a single dose of DMBA (50mg/kg) diluted in sesame oil (1 ml), group III: Graviola 200 mg/kg two times per week given orally by gavage from the first day of the experiment till the end plus a single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given orally at age of 57 days and group IV: rats treated with single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given orally plus graviola 200 mg/kg two times weekly both at age of 57 days till the end. After 30w the animals were anaesthetized to collect blood samples to determine the hepatic and renal protection of graviola. Treatment with graviola significantly (p< 0.05) reduced ALT activity and creatinine level. We can conclude that graviola mitigated hepatic and kidney functions. | ||||
Keywords | ||||
breast cancer; Graviola; Liver; Kidney, Histopathology, Body weight | ||||
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