Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents | ||||
| Journal of Advanced Pharmacy Research | ||||
| Article 1, Volume 2, Issue 1, January 2018, Page 1-19 PDF (507.11 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/aprh.2017.4832 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mai Adel  ; Rabah A. T. Serya; Deena S. Lasheen; Khaled A A. M. Abouzid
| ||||
| Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||||
| Abstract | ||||
| Pyrrolopyrimidine derivatives comprise a class of biologically active heterocyclic compounds that are well known to play a critical role in pharmaceutical drug design and health care. The pyrrolopyrimidines serve as promising scaffolds that were found in a number of biologically active compounds including antibiotics, anti-inflammatory, anti-viral and anticancer. Researchers were inspired to develop novel pyrrolopyrimidine derivatives for the treatment of Cancer. Currently several pyrrolopyrimidines are available commercially as anticancer drugs. The present review article offers a detailed account on the development of pyrrolopyrimidine derivatives with anticancer potential with emphasis on their activity as targeted kinase inhibitors. | ||||
| Keywords | ||||
| Anti-cancer; Protein kinases; Pyrrolopyrimidine | ||||
|
Statistics Article View: 597 PDF Download: 1,201 |
||||
