Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 1, Volume 12, Issue 1, January 2008, Page 3-8 PDF (2.5 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2008.4868 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Ismail Samy | ||||
| Department of Obstetrics and Gynecology, Campus Benjamin Franklin-University Hospital, Homboldt University, Berlin, Germany | ||||
| Abstract | ||||
| Objectives : To study the effect of addition of low dose of rccombinant follicle stimulating honiionc(r-FSH) in culture media on oocytc maturation, fertilization, cleavage and pregnancy rates in women with polycyslic ovaries, Material and Methods : In a randomized study of 100 women in an IVF program, 50 patients with 674 germinal vesicle (GV) oocytes were allocated to study the effect of low concentration dose of r-FSH (0.0 and O.075) supplemented in culture media on oocytes maturation, fertilization, cleavage, and pregnancy rate. Results : Oocytc maturation rate significantly (P<0.05) increased from 47% al 0.0 (control) to 81% at 0.075 IU/ml of r-FSH concentration, respectively. Fertilization, cleavage, and clinical pregnancy rates showed a similar trend and significantly increased from 45% to 83% and from 32% to 80% and from 0 to 17% at the two r-FSH concentrations, respectively. Conclusions : The results suggested that r-FSH supplementation in the culture media concentration of 0,075 IU was optimum in the present study and improved GV maturation, fertilization, cleavage and pregnancy rales. | ||||
| Keywords | ||||
| oocytes; IVM; ICSI; fertilization; Pregnancy | ||||
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