Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats
Zayed, A., kamel, E., abdelsamee, A., abdullah, D. (2021). Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats. EKB Journal Management System, 27(5), 855-864. doi: 10.21608/zumj.2019.15421.1381
Amany Zayed; elsayed mohamed kamel; ahmed ahmed abdelsamee; doaa mohamed abdullah. "Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats". EKB Journal Management System, 27, 5, 2021, 855-864. doi: 10.21608/zumj.2019.15421.1381
Zayed, A., kamel, E., abdelsamee, A., abdullah, D. (2021). 'Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats', EKB Journal Management System, 27(5), pp. 855-864. doi: 10.21608/zumj.2019.15421.1381
Zayed, A., kamel, E., abdelsamee, A., abdullah, D. Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats. EKB Journal Management System, 2021; 27(5): 855-864. doi: 10.21608/zumj.2019.15421.1381

Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats

Zagazig University Medical Journal
Article 228, Volume 27, Issue 5, September 2021, Page 855-864  XML PDF (502.35 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.15421.1381
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Authors
Amany Zayed email 1; elsayed mohamed kamel2; ahmed ahmed abdelsameeorcid 3; doaa mohamed abdullahorcid 4
1Clinical Pharmacology department, faculty of medicine, zagazig university, zagazig, egypt
2clinical pharmacology department ,faculty of medicine, zagazig university
3Assistant professor of clinical pharmacology, clinical pharmacology Department, Zagazig University, Zagazig, Egypt, E mail :
4clinical pharmacology department, faculty of medicine, zagazig university, zagazig, egypt
Abstract
Abstract
Background: Pain is an unpleasant sensation experienced when tissues are damaged. Therapeutic management of pain requires consideration of many factors due multiplicity of etiopathogenesis.
Objectives: The present study was designed to assess and compare the analgesic effects of gabapentin, diclofenac and tizanidine as well as their combinations in acute and chronic pain.
Methods: 128 rats were randomly allocated into two main equal categories; one for acute inflammatory and other for chronic neuropathic pain study. The acute category was divided into 8 equal groups; control, carrageenan, diclofenac, gabapentin, tizanidine, gabapentin-diclofenac, gabapentin-tizanidine and tizanidine-diclofenac groups. Acute inflammatory pain was induced by carrageenan injection in the animals paw. In the chronic category neuropathic pain was induced by right sciatic nerve ligation except for control and sham groups. This category was divided into; control, sham, gabapentin, tizanidine, gabapentin-diclofenac, gabapentin-tizanidine and tizanidine-diclofenac groups. The mean reaction time was assessed in all groups.
Results: In acute pain the three drugs and their combinations had significant analgesic effects. Tizanidine potentiated the analgesic effects of diclofenac and gabapentin. In chronic neuropathic pain diclofenac and gabapentin had significant analgesic action while, tizanidine had no analgesic effect.
Conclusion: Tizanidine didn’t show analgesic effect on chronic pain but potentiated the analgesic effect of gabapentin and diclofenac in acute pain model.
Keywords
Acute pain; Neuropathic pain; Diclofenac; Gabapentin; Tizanidine
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