OCCUPATIONAL GENOTOXIC EFFECTS AMONG A GROUP OF NURSES EXPOSED TO ANESTHETIC GASES IN OPERATING ROOMS AT ZAGAZIG UNIVERSITY HOSPITALS
GE, B., SA, A., SS, E., AM, E., MA, H. (2018). OCCUPATIONAL GENOTOXIC EFFECTS AMONG A GROUP OF NURSES EXPOSED TO ANESTHETIC GASES IN OPERATING ROOMS AT ZAGAZIG UNIVERSITY HOSPITALS. EKB Journal Management System, 42(1), 105-122. doi: 10.21608/ejom.2018.4942
Borayek GE; Abou El-Magd SA; El-Gohary SS; El-Naggar AM; Hammouda MA. "OCCUPATIONAL GENOTOXIC EFFECTS AMONG A GROUP OF NURSES EXPOSED TO ANESTHETIC GASES IN OPERATING ROOMS AT ZAGAZIG UNIVERSITY HOSPITALS". EKB Journal Management System, 42, 1, 2018, 105-122. doi: 10.21608/ejom.2018.4942
GE, B., SA, A., SS, E., AM, E., MA, H. (2018). 'OCCUPATIONAL GENOTOXIC EFFECTS AMONG A GROUP OF NURSES EXPOSED TO ANESTHETIC GASES IN OPERATING ROOMS AT ZAGAZIG UNIVERSITY HOSPITALS', EKB Journal Management System, 42(1), pp. 105-122. doi: 10.21608/ejom.2018.4942
GE, B., SA, A., SS, E., AM, E., MA, H. OCCUPATIONAL GENOTOXIC EFFECTS AMONG A GROUP OF NURSES EXPOSED TO ANESTHETIC GASES IN OPERATING ROOMS AT ZAGAZIG UNIVERSITY HOSPITALS. EKB Journal Management System, 2018; 42(1): 105-122. doi: 10.21608/ejom.2018.4942

OCCUPATIONAL GENOTOXIC EFFECTS AMONG A GROUP OF NURSES EXPOSED TO ANESTHETIC GASES IN OPERATING ROOMS AT ZAGAZIG UNIVERSITY HOSPITALS

Egyptian Journal of Occupational Medicine
Article 8, Volume 42, Issue 1, January 2018, Page 105-122  XML PDF (467.56 K)
Document Type: Study paper
DOI: 10.21608/ejom.2018.4942
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Authors
Borayek GE1; Abou El-Magd SA1; El-Gohary SS1; El-Naggar AM2; Hammouda MA1
1Department of Industrial Medicine and Occupational Health
2Department of Clinical Pathology, Faculty of Medicine, Zagazig University.
Abstract
from the patient’s anesthetic breathing circuit into the air of operating rooms during delivery of anesthesia. Personnel who are working in operating rooms are most likely to be exposed to waste anesthetic gases with no or bad automatic ventilation or scavenging systems. Aim of the work: The current study aimed to assess the level of biological marker of anesthetic gases and identify genotoxic effects among operating room nurses in Zagazig University Hospitals. Materials and methods: This study was conducted in Zagazig University Hospitals on 64 nurses who were divided into two groups: operating room nurses as exposed group, matched with outpatient clinic nurses as non exposed group. The data were collected using a questionnaire including demographic data, occupational, medical, family histories and complaints. Laboratory investigations done including Karyotyping of the chromosomes to assess genotoxic effects and assessment of urinary isoflurane. Results: Our study showed that there were highly statistical significant difference between both groups regarding occurrence of threatened and spontaneous abortion, repeated abortion> 2 times, congenital anomalies and symptoms during work as headache and dizziness. Also this work showed that chromosomal aberrations were present among about 59% of the exposed group, compared to 12.5% of non-exposed with highly statistically significant difference . The most common form of abnormalities were breaks of chromosomes (31.3%), fragments (18.8%) and polyploidy (6.2%). There were statistical significant difference between exposed and non-exposed in number of abnormal chromosomes and urinary isoflurane. Conclusion: Exposure to some anesthetic gases is associated with genotoxic effects among operating room personnel, leading to increased morbidity.
Keywords
Inhalational anesthetics; Halogenated anesthetic; Volatile anesthetics and Gene structure
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