CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?
Goda, H., Warda, O., Hady, E., Nezar, M., El-Said, M., El-Refaie, A., Ragab, A. (2007). CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?. EKB Journal Management System, 11(1), 15-22. doi: 10.21608/egyfs.2007.4950
Hossam Goda; Osama Warda; El-Said Hady; Mohamed Nezar; Maisaa El-Said; Abdel-Aziz El-Refaie; Ahmad Ragab. "CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?". EKB Journal Management System, 11, 1, 2007, 15-22. doi: 10.21608/egyfs.2007.4950
Goda, H., Warda, O., Hady, E., Nezar, M., El-Said, M., El-Refaie, A., Ragab, A. (2007). 'CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?', EKB Journal Management System, 11(1), pp. 15-22. doi: 10.21608/egyfs.2007.4950
Goda, H., Warda, O., Hady, E., Nezar, M., El-Said, M., El-Refaie, A., Ragab, A. CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?. EKB Journal Management System, 2007; 11(1): 15-22. doi: 10.21608/egyfs.2007.4950

CAN INFECTION WITH CYTOMEGALOVIRUS, PARVOVIRUS B19 AND HERPES SIMPLEX VIRUS CAUSE RECURRENT PREGNANCY LOSS?

The Egyptian Journal of Fertility of Sterility
Article 3, Volume 11, Issue 1, January 2007, Page 15-22  XML PDF (2.24 MB)
Document Type: Original Article
DOI: 10.21608/egyfs.2007.4950
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Authors
Hossam Goda1; Osama Warda1; El-Said Hady2; Mohamed Nezar3; Maisaa El-Said4; Abdel-Aziz El-Refaie1; Ahmad Ragab1
1From the Department of Obstetrics & Gynecology,Faculty of Medicine, Mansoura University .
2Department of Obstetrics & Gynecology,Faculty of Medicine, Mansoura University
3From the Department of Obstetrics & Gynecology,Faculty of Medicine, Mansoura University
4Department of Clinical Pathology Faculty of Medicine, Mansoura University .
Abstract
Objective: This study aimed to assess the probability of cylomegalovirus, parvovirus B 19, and herpes simplex 1, 2 virus
infection to cause recurrent miscarriage.
Study Design: Prospective study.
Settings: Antenatal outpatient clinic of Mansoura University Hospital and Clinical pathology department, faculty of
Medicine, Mansoura University during the period from February 2005 to September 2006
Methods: Patients included in the study were collected from those attending (he antenatal outpatient clinic of Mansoura
University Hospitals and were grouped into 2 groups; those with prior recurrent miscarriage (3 or more), with no
uterine malformation that may be a cause of recurrent miscarriage (excluded by hyslerosalpingograms) (11=50). The
other group included 12 women with normal pregnancy used as control. Blood samples were taken from each woman c<:
sent to the clinical pathology department for detection Ig M by ELISA & PCR for the genomes,
Results: Parvovirus IgM had the highest rate (84%) followed by HSVI. 2 IgM (50%) and CMV IgM (12%) ill the
recurrent abortion group. In controls, only parvovirus B19 IgM was positive in 2 cases (16.7%). In PCR study for viral
DNA, parvovirus B19 was positive in 24 cases (48%), HSV2 in 16 cases (32%) and CMV was positive in 6 cases
(12%) in recurrent abortion group with statistically significant difference between both groups.
Conclusion: We can conclude that viral infections might play a role in recurrent abortion especially parvovirus B19 and
HSV2.
Keywords
Parvovirus B 19; Herpes simplex; cylomegalovirus; PCR; recurrent miscarriage
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