PREVENTIVE MEASURES OF OVARIAN HYPERSTIMULATION SYNDROME | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Reviewers, Volume 10, Issue 1, January 2006, Page 3-8 PDF (419.76 K) | ||||
| DOI: 10.21608/egyfs.2006.4991 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Aboubakr Elnashar | ||||
| Department of Gynecology and Obstetrics. Benha University Hospital, Egypt | ||||
| Abstract | ||||
| Objective : To review the up-to-date randomized controlled trials (RCT) & meta-analyses concerning prevention of ovarian hyperstimulation syndrome (OHSS). Designs: An electronic search of the Cochrane library, Pub Mcd for RCT & meta-analyses concerning OHSS from 1990 to 2005. Results : Six Cochrane systematic reviews, 4 rncta-analyscs & 28 ReT were reviewed as regarding choice of the treatment regimen, preventive measures on the day of human chorionic gonadotrpin (HCG), on the day of oocyte retrieval, at the time of embryo transfer & during the luteal phase. Conclusions: l. Laparoscopic ovarian drilling & usc or urinary follicle stimulating homone (uFSH) rather than human menopausal gonadotropin (HMG) in stimulation cycles without concomitant use of a GnRh-a are associated with reduction of OHSS in polycystic ovary syndrome (PCOS). 2. Significant reduction in incidence of OHSS is observed with low dose step up FSH protocol. 3. Recombinant luteinising homonc (rLH) results in a highly significant reduction in OHSS compared to urinary luteinising hormone (uHCG). 4. Use of gonadotropin releasing hormone agonist (GnRHa) instead of HCG in antagonist protocol is associated with reduction of OHSS. 5. There is insufficient evidence to determine if coasting is an effective strategy for preventing OHSS 6. Administration of human albumin is not effective in reduction of severe OHSS. 7. Given the increased risk of OHSS associated with HeG, intramuscular (1M) progesterone is favored for luteal phase supplementation. | ||||
| Keywords | ||||
| Ovarian hyperstimulaticn syndrome; controlled ovarian hypcrstimulation; assisted reproductive; Technologies | ||||
|
Statistics Article View: 160 PDF Download: 261 |
||||
