Synthesis and Study Antimicrobial Activities of Some Novel Tetrazole Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 18, Volume 61, Issue 1, January and February 2018, Page 197-206 PDF (1.58 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2018.2214.1178 | ||||
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| Authors | ||||
Maher Nessim   1; Safaa I. Elewa2; Manal G. Mohamed1
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| 1Egyptian Petroleum Research Institute | ||||
| 2Faculty of women for arts, science and education, Ain Shams University | ||||
| Abstract | ||||
| Four (2-phenol derivatives) were coupled with 1H-tetrazole-5-diazonium chloride to synthesize four new compounds namely Ta-d. These prepared Azophenols reacted with two 4-alkoxy acids (8 and 10) to form two new series of 4-((1H-tetrazol-5-yl) diazenyl)-2-(R)-phenyl-4-(octyloxy) benzoates T8a-d and 4-((1H-tetrazol-5-yl)diazenyl)-2-(R)-phenyl-4-(decyloxy) benzoates T10a-d respectively. The structures of the twelve synthesized compounds were confirmed using the conventional tools of analysis, Elemental Analysis, FT-IR and 1H-NMR spectroscopy. They were tested as anti-fungi and anti-bacteria. Most of the prepared compounds possessed good antimicrobial action for Gram Positive and Gram-Negative Bacteria, whereas they gave no action on Aspergillus Fumigatus or Candida albicans. | ||||
| Keywords | ||||
| Tetrazoles; Diazotization; phenols; 1H-NMR; Biological Activity | ||||
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