Clusterin and Psoriasis; What is the Relation? | ||||
| International Journal of Medical Arts | ||||
| Article 1, Volume 2, Issue 1, January 2020, Page 152-156 PDF (219.35 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2019.12703.1005 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Osama Hashem   1; Zakaria Obaid1; Heshm Abd Alsamee2; Fatma Youssef3
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| 1Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egypt | ||||
| 2Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt | ||||
| 3Damietta General Hospital, Ministry of Health, Egypt. | ||||
| Abstract | ||||
| Background: Atherosclerotic infarction accounts for a sizable proportion of cerebral infarcts whether occurs from extracranial or intracranial atherosclerotic disease. Despite recent studies on stroke risk factors; it is still unclear whether or not single risk factor specifically affect extracranial or intracranial arteries in stroke patients. Aim of the work: To determine the difference between intracranial and extracranial steno-occlusive atherosclerosis and its correlation with risk factors of acute ischemic stroke using Magnetic Resonance Angiogram (MRA) and/or Computed Tomography Angiography (CTA) with Duplex. Patients and methods: All cases diagnosed as acute ischemic stroke were subjected to detailed history, full neurological examination, routine laboratory tests, extracranial vessels assessed by duplex, intracranial vessels assessed by MRA and/or CTA. Results: 61 patients included in the study (38 males and 23 females), with mean age (64.5 ± 11.4). Extracranial stenosis was (57 patients, 93.4%), while intracranial stenosis was (49 patients, 80.3%). But the intracranial significant stenosis was (45 patients, 73.77%), while the extracranial significant stenosis (26 patients, 42.62%). Hypertension (72.1%), obesity (62.3%), diabetes (57.4%), dyslipidemia (54.1%) and smoking (39.3%), were risk factors equally affecting the extracranial and the intracranial systems in the same descending order. There was a higher prevalence of hypertension among patients with intracranial significant stenosis showing a significant P-value of 0.048. Conclusion: Extracranial stenosis was more common than the intracranial stenosis, but the intracranial significant stenosis is more prevalent than the extracranial. Hypertension is a significant risk factor for intracranial significant stenosis | ||||
| Keywords | ||||
| Psoriasis; Clusterin; Psoriasis Area Severity Index; Keratinocyte; Apolipoprotein J | ||||
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