Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats
Abd-Elhakam, H., El-Deeb, T., Abd-Ellah, H., Shoman, M., Beshr, E., Abdel-Aziz, M., Nazmy, M. (2019). Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats. EKB Journal Management System, 2(4), 185-190. doi: 10.21608/jabps.2019.15584.1053
Hend A. Abd-Elhakam; Thoraya S. El-Deeb; Heba H. Abd-Ellah; Mai E. Shoman; Eman A. M. Beshr; Mohamed Abdel-Aziz; Maiiada H. Nazmy. "Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats". EKB Journal Management System, 2, 4, 2019, 185-190. doi: 10.21608/jabps.2019.15584.1053
Abd-Elhakam, H., El-Deeb, T., Abd-Ellah, H., Shoman, M., Beshr, E., Abdel-Aziz, M., Nazmy, M. (2019). 'Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats', EKB Journal Management System, 2(4), pp. 185-190. doi: 10.21608/jabps.2019.15584.1053
Abd-Elhakam, H., El-Deeb, T., Abd-Ellah, H., Shoman, M., Beshr, E., Abdel-Aziz, M., Nazmy, M. Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats. EKB Journal Management System, 2019; 2(4): 185-190. doi: 10.21608/jabps.2019.15584.1053

Synthesized oxime and ketone derivatives of ibuprofen have higher hepatic safety profile and hepatoprotective potential against acute CCl4 - induced hepatotoxicity in rats

Journal of advanced Biomedical and Pharmaceutical Sciences
Article 5, Volume 2, Issue 4, October 2019, Page 185-190  XML PDF (983.75 K)
Document Type: Original Article
DOI: 10.21608/jabps.2019.15584.1053
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Authors
Hend A. Abd-Elhakam1; Thoraya S. El-Deeb2; Heba H. Abd-Ellah3; Mai E. Shomanorcid 3; Eman A. M. Beshr3; Mohamed Abdel-Aziz3; Maiiada H. Nazmy email 1
1Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
2Department of Biochemistry, Faculty of Medicine, Assiut University, 71515 Assiut, Egypt
3Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
Abstract
Despite previously reported high hepatic safety profile of ibuprofen (IBP), but other reports oppose its use in hepatic patients. The aim of this study is to evaluate the possible effect of IBP besides its oxime (OI) and ketone (KI) derivatives in both normal liver and in acute CCl4-induced hepatotoxicity. Sixty adult male Wistar rats were used, divided into 8 groups. Group 1: received saline water as normal control. Groups 2,3,4: treated with IBP, OI or KI respectively. Group 5: treated with CCl4 to induce hepatotoxicity. Groups 6,7,8: treated with IBP, OI or KI respectively 30 minutes before CCl4 administration. Current results showed that despite the apparent hepatotoxic effects of IBP, which were less evident in OI and KI, on normal liver that may be explained by possible immunological idiosyncrasy, they ameliorated both hepatocellular and cholestatic damage induced by CCl4, which may be attributed to their anti-inflammatory and anti-oxidant potential. OI and KI derivatives, rather than IBP, showed higher hepatic safety profile and stronger hepatoprotective potential against acute CCl4-induced hepatotoxicity, which favor their use, instead of IBP, in concurrent hepatic diseases.
Keywords
Ibuprofen; Oxime; Ketone; Carbon tetrachloride; Hepatotoxicity
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