Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study)
Zaki, H., Farid, M., El Shiekh, M. (2017). Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study). EKB Journal Management System, 4(2), 139-146. doi: 10.21608/adjg.2017.5219
Heba Zaki; Mona Farid; Marwa El Shiekh. "Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study)". EKB Journal Management System, 4, 2, 2017, 139-146. doi: 10.21608/adjg.2017.5219
Zaki, H., Farid, M., El Shiekh, M. (2017). 'Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study)', EKB Journal Management System, 4(2), pp. 139-146. doi: 10.21608/adjg.2017.5219
Zaki, H., Farid, M., El Shiekh, M. Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study). EKB Journal Management System, 2017; 4(2): 139-146. doi: 10.21608/adjg.2017.5219

Evaluation of the Effect of Platelet Rich Fibrin on Alveolar Socket Healing in Glucocorticoids-Induced Osteoporosis in Rabbits (Histological and Immuno-histomorphometric study)

Al-Azhar Dental Journal for Girls
Article 6, Volume 4, Issue 2, April 2017, Page 139-146  XML PDF (362.42 K)
Document Type: Original Article
DOI: 10.21608/adjg.2017.5219
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Authors
Heba Zaki1; Mona Farid2; Marwa El Shiekh3
1Demonstrator of Oral and Dental Biology, Oral and Dental Biology Department, Faculty of Dental Medicine, Al-Azhar University for Girls.
2Professor and Head of Oral and Dental Biology Department, Faculty of Dental Medicine, Al-Azhar University for Girls.
3Lecturer of Oral and Dental Biology, Oral and Dental Biology Department, Faculty of Dental Medicine, Al-Azhar University for Girls.
Abstract
Purpose: The purpose of this study was to evaluate the effect of platelet rich fibrin  on the healing of osteoporotic alveolar socket after tooth extraction in experimentally induced osteoporosis in rabbits. Materials and Methods: Thirty six adult female rabbits were used in this study. Rabbits were divided into 3 groups (group1, group2 &group 3: 12 for each group) then each group was divided into 3 subgroups (4 for each subgroups) according to the date of scarification at 7, 20, 30 days postoperatively. Group 1: (12 rabbits), alveolar socket was left empty after first molar extraction (didn’t receive
Platelet Rich Fibrin (PRF)). For the remaining 24 female rabbits: osteoporosis was experimentally induced by receiving 1.56 mg/kg dexamethasone (Dex) intraperitoneal injection daily for 2 months to induce osteoporosis - like condition. Group 2: (12 rabbits), osteoporotic alveolar sockets were left empty after first molar extraction (didn’t receive PRF). Group 3: (12 rabbits), osteoporotic alveolar socket received PRF after first molar extraction. The specimens were collected, prepared and examined by routine haematoxylin &eosin and immunostained by Osteoprotogrin (OPG) marker. Results: at 7, 20 and 30 days, the greatest mean value was recorded in group 1, followed by group 3, with the least value recorded in group 2. Both group 1and 3 revealed a decrease in area percent of OPG throughout the study, whereas in group 2 revealed an increase. Conclusions: The study offers a clear evidence that topical application of PRF in osteoporotic alveolar socket after tooth extraction accelerates and increases the rate of bone formation and maturation than in osteoporotic alveolar socket without PRF. 
Keywords
Platelet- rich fibrin (PRF); alveolar socket; glucocorticoids (GCs); Osteoporosis; Osteoprotogrin (OPG)
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