EMBRYOTOXICITY AND TERATOGENICITY OF FIPRONIL IN RATS (Rattus norvegicus)
Eisa, A., Abo-Elghar, G., Ammar, I., Metwally, H., Arafa, S. (2017). EMBRYOTOXICITY AND TERATOGENICITY OF FIPRONIL IN RATS (Rattus norvegicus). EKB Journal Management System, 44(5), 1851-1861. doi: 10.21608/zjar.2017.52265
Amal A. Eisa; G. E. Abo-Elghar; I. M. Ammar; Hala G. Metwally; Samah S. Arafa. "EMBRYOTOXICITY AND TERATOGENICITY OF FIPRONIL IN RATS (Rattus norvegicus)". EKB Journal Management System, 44, 5, 2017, 1851-1861. doi: 10.21608/zjar.2017.52265
Eisa, A., Abo-Elghar, G., Ammar, I., Metwally, H., Arafa, S. (2017). 'EMBRYOTOXICITY AND TERATOGENICITY OF FIPRONIL IN RATS (Rattus norvegicus)', EKB Journal Management System, 44(5), pp. 1851-1861. doi: 10.21608/zjar.2017.52265
Eisa, A., Abo-Elghar, G., Ammar, I., Metwally, H., Arafa, S. EMBRYOTOXICITY AND TERATOGENICITY OF FIPRONIL IN RATS (Rattus norvegicus). EKB Journal Management System, 2017; 44(5): 1851-1861. doi: 10.21608/zjar.2017.52265

EMBRYOTOXICITY AND TERATOGENICITY OF FIPRONIL IN RATS (Rattus norvegicus)

Zagazig Journal of Agricultural Research
Article 21, Volume 44, Issue 5, September 2017, Page 1851-1861  XML PDF (287.12 K)
Document Type: Original Article
DOI: 10.21608/zjar.2017.52265
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Authors
Amal A. Eisa email 1; G. E. Abo-Elghar1; I. M. Ammar1; Hala G. Metwally2; Samah S. Arafa1
1Pest. Dept., Fac. Agric., Menoufia Univ., Egypt
2Clin. Pathol. Dept., Fac. Med., Cairo Univ., Egypt
Abstract
Teratogenic and embryotoxic effects of fipronil insecticide were studied following orally intubation of pregnant female rats. The animals were treated with different doses 1/10 LD50 (2.1 mg/kg b.wt) and 1/30 LD50 (0.7 mg/kg b.wt) at the 6th to 15th days of pregnancy (time of organogenesis). At the 20th days of pregnancy, pregnant females were subjected to a caesarean section. The effect of the fipronil on fetal development was evaluated. Maternal weight gain decreased at 1/10 and 1/30 LD50 of fipronil. The body weight and length of viable fetuses significantly decreased with both tested doses. Visceral examination revealed cleft palate, heart and lungs hypoplasia, liver and kidneys atrophy increased with fipronil treatments at different doses. Skeletal examination showed incomplete ossification of the skull bones, short ribs, coccygeal absences, sternbrae abscence and digits of fore and hind limbs.
Keywords
Fipronil; Rattus norvegicus; teratogenicity; visceral anomalies; skeletal abnormalities
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