Effect of Cholecalciferol Supplementation on Glycemic Control, Beta Cell Function and Insulin Resistance among Type 2 Diabetics Attending the Family Medicine Outpatient Clinic Affiliated to Suez Canal University Hospital, Ismailia City, Egypt | ||||
| The Medical Journal of Cairo University | ||||
| Article 54, Volume 87, March, March 2019, Page 435-443 PDF (682.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.52379 | ||||
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| Authors | ||||
| DALIA E. IBRAHIM, M.Sc.; HASSAN A. ABD EL-WAHED, M.D.;; HANAN A. ABDO, M.D.; ENAYAT M. SOLTAN, M.D. | ||||
| The Department of Family Medicine, Faculty of Medicine, Suez Canal University | ||||
| Abstract | ||||
| Abstract Background: Diabetes is a complex chronic illness that adversely affects patients' quality of life. Approximately 425 million adults (20-79 years) were living with diabetes in 2017. Vitamin D levels had been shown to alter insulin synthesis and secretion suggesting its role in the pathogenesis of type 2 diabetes mellitus. Aim of Study: To promote the quality of care provided to type 2 diabetic patients in the family practice setting. Patients and Methods: This is a randomized controlled trial conducted on 60 uncontrolled type 2 diabetics. Patients were randomly allocated to Vitamin D3 group; received oral daily 2000IU of Cholecalciferol plus their usual care and a control group; received only their usual care for 3 months. Baseline anthropometrics, blood pressure, FBS, HBA1C, fasting insulin, HOMA indices and lipid profile were measured and repeated after 3 months. Results: No statistically significant sociodemographic differences were found between both groups. The majority were younger than 60 years, hypertension was found in 76.7% of them. There were post intervention statistically significant differences (p<0.05) between both groups in blood pressure, FBS and HOMA-b. The pre-post relation in the intervention group shows statistically significant differences (p<0.05) in blood pressure, FBS, fasting insulin, HOMA-b and HOMA-IR. There is a statistically significant positive correlation between HBA1C, blood pressure, and FBS. Conclusion: Adding a daily dose of 2000IU of oral Vitamin D3 for type 2 diabetic patients may be beneficial through improving blood pressure, fasting blood glucose and HOMA-b. | ||||
| Keywords | ||||
| diabetes; Cholecalciferol; HbA1c; HOMA-b; HOMA-IR | ||||
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