Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C
YEHIA M. YOUSSEF, M.D., R., OLA A. EL-SAYED, M.D., M., TOLBA, M.D., A. (2019). Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C. EKB Journal Management System, 87(March), 547-555. doi: 10.21608/mjcu.2019.52420
REEM H. MOHAMED, M.Sc.; YEHIA M. YOUSSEF, M.D.; MANAL H. EL-KAFRAWY, M.D.; OLA A. EL-SAYED, M.D.; AMINA M. TOLBA, M.D.. "Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C". EKB Journal Management System, 87, March, 2019, 547-555. doi: 10.21608/mjcu.2019.52420
YEHIA M. YOUSSEF, M.D., R., OLA A. EL-SAYED, M.D., M., TOLBA, M.D., A. (2019). 'Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C', EKB Journal Management System, 87(March), pp. 547-555. doi: 10.21608/mjcu.2019.52420
YEHIA M. YOUSSEF, M.D., R., OLA A. EL-SAYED, M.D., M., TOLBA, M.D., A. Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C. EKB Journal Management System, 2019; 87(March): 547-555. doi: 10.21608/mjcu.2019.52420

Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C

The Medical Journal of Cairo University
Article 67, Volume 87, March, March 2019, Page 547-555  XML PDF (887.74 K)
Document Type: Original Article
DOI: 10.21608/mjcu.2019.52420
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Authors
REEM H. MOHAMED, M.Sc.; YEHIA M. YOUSSEF, M.D.; MANAL H. EL-KAFRAWY, M.D.; OLA A. EL-SAYED, M.D.; AMINA M. TOLBA, M.D.
The Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo
Abstract
Abstract
Background: Cisplatin has a major nephrotoxic effect.
Aim of Study: To evaluate the protective effect of vitamin C against cisplatin-induced nephrotoxicity.
Material and Methods: Sixty adult albino rats divided into 5 groups; group I (10 rats; control), group II (10 rats); received single dose of cisplatin 6mg/kg IP. Group III (10 rats); received single dose of cisplatin 6mg/kg IP 6 hours after single dose of oral vitamin C 350mg/kg. Group IV (15 rats); received single dose of cisplatin 2mg/kg/week for 4 weeks IP and subdivided into three subgroups (5 rats each). Group V (15 rats); received single dose of cisplatin 2mg/kg/week for 4 weeks IP 6 hours after single dose of oral vitamin C 350mg/kg and subdivided into three subgroups (5 rats each). Kidneys were dissected and stained by (H&E), Masson's trichrome (MT) and Periodic acid Schiff (PAS) and examined by light microscopy, and fresh tissue taken from group I, IV-
B and V-C examined by electron microscopy.
Results: Our results showed toxic effect of cisplatin on renal glomeruli and proximal tubular lining in group II with improvement in group III, chronic toxicity effect in group IV-
C in the form of hyaline casts and thickened BM with apparent improvement in group V.
Conclusion: We conclude that the vitamin C has a protec-tive effect against cisplatin- induced nephrotoxicity.
Keywords
kidney; Cisplatin; vitamin c; EM
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