The Effect of Various Elements Substitution on Properties of Bioactive Glass Scaffolds for Bone Tissue Engineering. | ||||
| Al-Azhar Dental Journal for Girls | ||||
| Article 9, Volume 4, Issue 3, July 2017, Page 255-270 PDF (685.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjg.2017.5266 | ||||
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| Authors | ||||
| Fatma Abdul-Rahman1; Inas Motawea2; Eatimad Shoreibah3 | ||||
| 1Assistant Lecturer of Dental Biomaterials, Faculty of Dental Medicine for Girls, Al-Azhar University. | ||||
| 2Assistant Professor and Head of Dental Biomaterials Department, Faculty of Dental Medicine for Girls, Al- Azhar University | ||||
| 3Professor of Oral Medicine & Periodontology, Faculty of Dental Medicine for Girls, Al-Azhar University. | ||||
| Abstract | ||||
| Aim: The aim of the present study was to synthesize and characterize sol-gel derived bioactive glass scaffold and evaluate the effect of substitution of Zirconium (Zr), Strontium (Sr), and Zinc (Zn) on the their bioactivity, biodegradability and mechanical properties. Materials and Methods: Bioactive glass scaffold samples with compositions 80% SiO2-15%CaO and 5% P2O5 and 75 % SiO2-15% CaO - 5% P2O5 and 5% MO (in mol%) (M=Sr, Zr or Zn) were synthesized using the sol–gel combined with foam replication method. The scaffolds were characterized by DTA, XRD, SEM and FTIR spectroscopy. Their mechanical properties were measured and their bioactivity/ biodegradability were evaluated in simulating body fluid (SBF). Results: All the scaffolds showed no distinct difference in phase composition, macroporous structure, percent porosity or pore size distribution. Conclusions: Sr, Zr and Zn substitution decreased the mechanical properties of the bioglass system. Sr and Zr ions enhanced the formation of nano-structured hydroxycarbonate apatite (HCA) layer, whereas Zn ions diminished the bioactivity. Moreover, Sr ions increased the biodegradability of the bioglass system. | ||||
| Keywords | ||||
| Bioactive glass; hydroxycarbonate apatite; ions substitution | ||||
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