Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II) | ||||
Egyptian Journal of Chemistry | ||||
Article 21, Volume 63, Issue 5, May 2020, Page 1857-1868 PDF (1.49 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2019.16748.2019 | ||||
View on SCiNiTO | ||||
Authors | ||||
Nadia G. Zaki1; Walaa H. Mahmoud 2; Ahmed M. El Kerdawy 3; Abanoub Abdallah 1; Gehad G. Mohamed 2 | ||||
1Narcotic Research Department, National Center for Social and Criminological Research (NCSCR), Giza 11561, Egypt | ||||
2Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt | ||||
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt | ||||
Abstract | ||||
Reaction of cocaine (Cn) with Mn(II) and Cu(II) chloride salts afforded complexes of the [M(Cn)Cl(OH2)3]Cl type which were structurally characterized by elemental analysis, conductance measurements, spectroscopic methods and mass spectroscopy. Their thermal properties were studied. The in vitro antitumor activity of the newly synthesized complexes was investigated by MTT assay on MCF-7 and HepG-2 cell lines. Both complexes exhibited promising cytotoxic activity on both cell lines with high safety on normal human cells. Their antifungal activity against Aspergillus fumigatus and Candida albicans and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium and Escherichia coli were also included. | ||||
Keywords | ||||
Cocaine; Transition metal complexes; thermal analyses; Antiproliferative activity; antimicrobial activity | ||||
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