Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives
Rizk, S., Youssef, M., Mubarak, A. (2020). Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives. EKB Journal Management System, 63(5), 1767-1777. doi: 10.21608/ejchem.2019.16936.2036
Sameh A. Rizk; Mohamed Fathy Youssef; Ahmed M. Mubarak. "Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives". EKB Journal Management System, 63, 5, 2020, 1767-1777. doi: 10.21608/ejchem.2019.16936.2036
Rizk, S., Youssef, M., Mubarak, A. (2020). 'Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives', EKB Journal Management System, 63(5), pp. 1767-1777. doi: 10.21608/ejchem.2019.16936.2036
Rizk, S., Youssef, M., Mubarak, A. Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives. EKB Journal Management System, 2020; 63(5): 1767-1777. doi: 10.21608/ejchem.2019.16936.2036

Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives

Egyptian Journal of Chemistry
Article 13, Volume 63, Issue 5, May 2020, Page 1767-1777  XML PDF (1.5 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.16936.2036
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Authors
Sameh A. Rizk email orcid 1; Mohamed Fathy Youssef2; Ahmed M. Mubarak2
1Faculty of Science– Chemistry Department, Ain Shams University
2Faculty of Science– Chemistry Department, Suez Canal University
Abstract
2-Aroylbenzoic acid was allowed to react with hydrazine hydrate, hydroxyl amine and methylhydrazine to afford the corresponding 5,6,7,8-tetrachlorophthalazin-1-one. The antimicrobial effect of the phthalazin-1-one in the water of the swimming pool and river can be discussed. DFT based on quantum chemical computational of the new compounds were synthesized with the objective of studying their antimicrobial activity. The newly synthesized compounds were characterized on the basis of their spectral (1H-NMR, Mass spectrum, IR and Elementary analysis
Keywords
phthalazine; DFT; Antimicrobial
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