Comparative Study between Topical Flutamide Alone or Combined with Carboxytherapy in Treatment of Patients with Melasma
GAMAL M. EL-MAGHRABY, M.D., A., HEMMAT M. EL-ADAWY, M.Sc., G. (2019). Comparative Study between Topical Flutamide Alone or Combined with Carboxytherapy in Treatment of Patients with Melasma. EKB Journal Management System, 87(March), 1099-1105. doi: 10.21608/mjcu.2019.53289
ARWA M. HASSAN, M.D.; GAMAL M. EL-MAGHRABY, M.D.; GHADA F.R. HASSAN, M.D.; HEMMAT M. EL-ADAWY, M.Sc.. "Comparative Study between Topical Flutamide Alone or Combined with Carboxytherapy in Treatment of Patients with Melasma". EKB Journal Management System, 87, March, 2019, 1099-1105. doi: 10.21608/mjcu.2019.53289
GAMAL M. EL-MAGHRABY, M.D., A., HEMMAT M. EL-ADAWY, M.Sc., G. (2019). 'Comparative Study between Topical Flutamide Alone or Combined with Carboxytherapy in Treatment of Patients with Melasma', EKB Journal Management System, 87(March), pp. 1099-1105. doi: 10.21608/mjcu.2019.53289
GAMAL M. EL-MAGHRABY, M.D., A., HEMMAT M. EL-ADAWY, M.Sc., G. Comparative Study between Topical Flutamide Alone or Combined with Carboxytherapy in Treatment of Patients with Melasma. EKB Journal Management System, 2019; 87(March): 1099-1105. doi: 10.21608/mjcu.2019.53289

Comparative Study between Topical Flutamide Alone or Combined with Carboxytherapy in Treatment of Patients with Melasma

The Medical Journal of Cairo University
Article 133, Volume 87, March, March 2019, Page 1099-1105  XML PDF (429.69 K)
Document Type: Original Article
DOI: 10.21608/mjcu.2019.53289
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Authors
ARWA M. HASSAN, M.D.; GAMAL M. EL-MAGHRABY, M.D.; GHADA F.R. HASSAN, M.D.; HEMMAT M. EL-ADAWY, M.Sc.
The Departments of Dermatology & Venereal Diseases, Faculty of Medicine* and Pharmaceutical Technology, Faculty of Pharmacy**, Tanta University
Abstract
Abstract
Background: Melasma is one of the most common causes of facial hyperpigmentation which causes cosmetic disfigure-ment and leads to psychological proplems, although various treatments are available for melasma, it remains a difficult condition to treat.
Aim of Study: To evaluate and compare the efficacy of topical flutamide 1% alone and in-combination with Carbox-ytherapy in treatment of patients with melasma.
Patients and Methods: The study included 30 female patients with different types and patterns of melasma. They were divided into two groups, each group included 15 patients: Group A, patients were treated with 1% flutamide topical gel on the face and group B, patients were treated with 1% flutamide topical gel on the face and carboxytherapy injection was done in both sides of the face every four weeks for three sessions.
Results: Both groups showed highly significant decrease in mMASI score after the treatment in which group B showed better results with (p-value=0.048*) than group A with (p-value=0. 007*).
Conclusion: As new treatment for melasma topical fluta-mide was effective and safe therapeutic modalities. Carboxy-therapy could be effective and safe new treatment modality for melasma as adjuvant treatment with topical flutamide.
Keywords
Topical Flutamide; Carboxytherapy; Melasma
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