Differential Expression of Autophagy-Related Marker (Beclin-1) in Relation to Clinicopathological Parameters in Different Breast Cancer Molecular Subtypes | ||||
| The Medical Journal of Cairo University | ||||
| Article 146, Volume 87, March, March 2019, Page 1209-1217 PDF (709.94 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.53334 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| RANIH Z. AMER, M.D.; SHAIMAA M.N. EL-ZAMLY, M.D.; HALA A. AGINA, M.D.; MONA A.M. ABO EL-KHAIR, M.Sc. | ||||
| The Department of Pathology, Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Abstract Background: Beclin-1 plays a vital role in the vesicle nucleation in the process of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Aim of Study: Study the role of beclin-1 and correlate the degree of its expression with available clinic-pathological data in different molecular types of breast cancer. Material and Methods: Immunohistochemistry was per-formed to examine the expression of Beclin-1 different mo-lecular subtypes of invasive ductal carcinoma and correlating it to clinicopathological parameter. Results: The expression of Beclin-1 was decreased in breast cancer in relation to normal tissue. High expression was significantly correlated with tumor grade, distant metas-tasis and stage. All the cases with high Beclin-1 expression were triple negative breast cancer cases. Conclusions: Triple negative breast cancer cases showed the highest tumor stage, grade, distant metastasis and beclin-1 expression suggesting that the overexpression of Beclin 1 may by itself confer an aggressive biological course. It could be a therapeutic target. | ||||
| Keywords | ||||
| Breast carcinoma; molecular subtypes; Au-tophagy, Beclin | ||||
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