Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients | ||||
The Egyptian Journal of Geriatrics and Gerontology | ||||
Article 4, Volume 2, Issue 1, March 2015, Page 19-26 PDF (328.51 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejgg.2015.5342 | ||||
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Authors | ||||
Salamah M1; Gad M.1; Deghady A.2; Elgayar H1 | ||||
1Geriatric Unit, Internal Medicine Department, Faculty of Medicine, Alexandria University | ||||
2Clinical Pathology Department, Faculty of Medicine, Alexandria University | ||||
Abstract | ||||
The aim of the study is to assess the effectiveness of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection in Egyptian elderly patients with normal liver and kidney functions. Methods: The study was experimental study carried out on 34 elderly patients having H. pylori gastritis with normal liver and kidney functions. We tested for H. pylori stool antigen using a quantitative monoclonal enzyme-linked immunosorbent assay (ELISA) assay before and 4 weeks after the treatment to confirm eradication. Patients received Clarithromycin-based triple therapy (Clarithromycin 500mg twice daily, Amoxicillin 1000mg twice daily, and Omeprazole 40mg twice daily) for H. pylori eradication for 14 days. Results: The cure rate of Clarithromycinbased triple therapy was 88.2% (30/34) and only 11.8% (4/34) was having persistent infection. None of the patients discontinued the drugs indicating good tolerability .Conclusion: The use of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection is highly effective and tolerable in Egyptian elderly patients with normal liver and kidney functions. | ||||
Keywords | ||||
Helicobacter pylori; Elderly; clarithromycin | ||||
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