Association of Ki-67 Expression and the Aggressiveness of Hepatocellular Carcinoma | ||||
| The Medical Journal of Cairo University | ||||
| Article 37, Volume 87, June, June 2019, Page 1649-1655 PDF (574.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.53903 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| WALAA G. EL-GENDY, M.Sc.; NANIS S. HOLAH, M.D.; DALIA R. EL-SHARAKY, M.D.; DINA S. EL-AZAB, M.D.; ASMAA G. ABDOU, M.D.; MOHAMMED T. BADR, M.D. | ||||
| The Department of Pathology, National Liver Institute* and Faculty of Medicine**, Menoufia University, Shebin El-Kom, Egypt | ||||
| Abstract | ||||
| Abstract Background: Ki-67 is a nuclear proliferative marker. It is therefore widely used as a cell proliferation marker to grade tumors. Aim of Study: The aim of the current study was to assess the possible association between Ki-67 and the aggressiveness of hepatocellular carcinoma. Material and Methods: This study was conducted at Pathology Department in National Liver Institute, Menoufia University. A total of 114 cases were included. TMA was performed for tumor blocks and stained with antibody against Ki-67. Results: The percentage of Ki-67 expression ranged between 1 and 95% with a mean ± SD of 56.72±40.53 and a median of 80. As regard Ki-67 expression, large tumor size group were significantly associated with increased expression of Ki-67 (p=0.049). On the other hand, older age group (>60 years) and large tumor size group (>5cm) were significantly associated with increased percentage of Ki-67 expression (p=0.035 and 0.015) respectively. Conclusion: Ki-67 expression is associated with aggressive hepatocellular carcinoma, so it could change the type of therapy for these tumors. | ||||
| Keywords | ||||
| Ki-67; Hepatocellular carcinoma; Aggressive-ness; TMA; expression | ||||
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