Immunohistochemical Expression of Yes-Associated Protein-1 (YAP-1) in Cutaneous Lichen Planus | ||||
| The Medical Journal of Cairo University | ||||
| Article 50, Volume 87, June, June 2019, Page 1769-1773 PDF (323.42 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.53963 | ||||
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| Authors | ||||
| RANIA A.R. EL-TATAWY, M.D.; DAREEN A. MOHAMED, M.D.; YOMNA MAZID EL-HAMD A. NEINAA, M.D; HEBA A.A. EL-BANBI, M.Sc. | ||||
| The Departments of Dermatology & Veneral Diseases* and Pathology**, Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| Abstract Background: Lichen planus is a chronic muco-cutaneous inflammatory disease that affects skin, mucous membranes, scalp, and nails. The exact pathogenesis of the disease remains unclear but cell-mediated cytotoxicity is regarded as a major mechanism of pathogenesis of lichen planus. Yes-Associated Protein (YAP-1) was originally identified in Drosophila as a key component of the Hippo pathway, which regulates cell proliferation, apoptosis and migration. Aim of Study: The aim of this work was to study YAP-1 expression in cutaneous lichen planus. Patients and Methods: This study was carried out on 20 patients with cutaneous LP and 10 normal skin specimens served as controls. All specimens were examined by H&E, and by immunohistochemistry for YAP-1 expression. Results: There was statistically significant increase of YAP-1 expression in lesional skin of lichen planus patients in comparison to normal skin of healthy controls. Conclusion: Increased expression of YAP-1 was found in cutaneous lichen planus in comparison to normal skin suggesting a possible role of YAP-1 in lichen planus patho-genesis. | ||||
| Keywords | ||||
| YAP-1; Immunohistochemistry; lichen planus | ||||
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