Can montelukast correct immune dysregulation in preschool children with mild persistent asthma? | ||||
The Egyptian Journal of Pediatric Allergy and Immunology | ||||
Article 6, Volume 17, Issue 2, October 2019, Page 87-95 PDF (312.7 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejpa.2019.53993 | ||||
View on SCiNiTO | ||||
Authors | ||||
Amany El-Kelany1; Maha Anani2; Hanan Omar3; Asmaa Hashem 4; Enas Fathy1 | ||||
1Department of Pediatrics, faculty of medicine, Suez Canal University, Ismailia, Egypt. | ||||
2Clinical pathology department, faculty of medicine, Suez Canal University, Ismailia, Egypt. | ||||
3Clinical pathology, faculty of medicine, Suez Canal University, Ismailia,Egypt. | ||||
4Microbiology and Immunology department, faculty of medicine, Suez Canal University, Ismailia, Egypt. | ||||
Abstract | ||||
Background: Asthma is the most common inflammatory disorder among preschool and school-age children. Regulation of immune cells and their cytokines is essential to control asthma. Montelukast is a leukotriene receptor antagonist that suppresses inflammatory cell proliferation, and reduces cytokines and mediator secretion. Objective: The research team's goal was to study the immunological parameters among mild asthmatic patients before and after the treatment with Montelukast . Methods: Forty preschool children with mild persistent asthma and twenty healthy, non-allergic children were included in the study. Blood eosinophil count, total IgE, serum IL-4, IL-10, and IL-13 levels were assessed. T helper (CD3+CD4+) and T regulatory (CD4+CD25+) cell counts were measured using flow cytometry; for mild asthmatics before and after six weeks of treatment with Montelukast and for the control group. Results: Asthmatic children have shown a significant elevation of serum levels of IgE, IL4 and IL13, and also an increase of eosinophils, total lymphocyte T cells and T helper cell count. However; serum levels of IL10 and Treg cell count was lower in asthmatics compared to control. Following six weeks of Montelukast treatment, all immunological parameters improved. There was a significant elevation of serum levels of IL10 and Treg cell count, with a decrease in serum levels of IgE, IL4 and IL13; eosinophil counts, and helper T cells. Conclusion: Montelukast treatment improves the impaired immunological balance of mild asthmatic children through the increase of serum IL-10, T regulatory cell counts that have anti-inflammatory and immunoregulatory effects. It also decreases T helper cells and their proinflammatory cytokines. | ||||
Keywords | ||||
Montelukast; Asthma; children; Egypt | ||||
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