Clinical outcomes of Tranexamic acid administration in Elective Cesarean Delivery :-Intra and post operative effects | ||||
| Zagazig University Medical Journal | ||||
| Article 267, Volume 27, Issue 4, July 2021, Page 700-706 PDF (325.87 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2019.16829.1512 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
ahmed roshdy zaky abdel aal  1; abdalla elsayed diab2; wael sabry nossair2; mohammed elhusseiny alkudousy3
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| 1Obstetrics and gynecology,zagazig university,sharkia | ||||
| 2Professor of Obstetrics and Gynecology Gynecology Faculty of Medicine - Zagazig University | ||||
| 3lecturer of Obstetrics and Gynecology Gynecology Faculty of Medicine - Zagazig University | ||||
| Abstract | ||||
| Background: we hoped to see efficacy of tranexamic acid (TA) on reducing blood loss during elective cesarean delivery and its outcomes intra and postoperatively .Patient and Methods: We carried out a randomized, double-blind, placebo-controlled study over 156 females who underwent elective CS. patients were randomly selected to receive an intravenous infusion of TA (1 g/10 mL in 100 mL of lactated ringer before surgery. The primary outcome was estimated blood loss following CS. No demographic difference was observed between sets. Results: mean estimated blood loss was significantly lower in females treated with TA in comparison with females in control set (389.75±187.6 ml versus 724.45±214.5 ml, respectively; p1000 ml was significantly lower than in control set 3 [3.8%] versus 14 [17.9%], respectively. TA significantly reduced the need for additional uterotonics, females in control set versus TA set 8 [10.3%] versus 3 [3.8%], respectively. Conclusion: Maternal outcomes in TA set is better than control set , decrease the incidence of intra-operative atony , minor ooze and need for drain ,also decreased hospital stay significantly, Protected patients from hazards of blood transfusion , reduce incidence of atonic postpartum which in sever cases may lead to hysterectomy , maternal morbidity and mortality. No incidence of thromboembolic events . fetal outcomes did not differ significantly. Our results suggest that TA can be used safely and effectively to reduce Bleeding during CS. Keywords: Tranexamic acid, cesarean delivery, bl00d lost, randomized control trial | ||||
| Keywords | ||||
| Tranexamic acid; Cesarean delivery; clinical outcomes; bl00d lost; randomized control trial | ||||
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