Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats | ||||
Egyptian Journal of Cancer and Biomedical Research | ||||
Article 4, Volume 2, Issue 2 - Serial Number 3, August 2018, Page 14-20 PDF (536.71 K) | ||||
Document Type: Original Article | ||||
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Authors | ||||
Elsayed I. Salim 1; Areeg Khalifa2 | ||||
1Zoology Department, Faculty of Science, Tanta University, Egypt | ||||
2Tanta University, Faculty of Science, Department of Zoology | ||||
Abstract | ||||
Background: Carcinogens become a serious environmental challenge. Aim: The main aim of this study was to assess the alterations in some biochemical parameters in male Wistar rats after. Materials and Methods: Experimental groups were administered with 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) followed by 5% Sodium ascorbate (Na-As), then they were post-treated with Nigella sativa (N. sativa) by an inter-gastric luminal gavage or with thymoquinone (TQ) by inter-peritoneal injections. Blood samples were collected after a 32 weeks’ experiment. Results: TQ seemed to have a powerful inhibitory effect on total cholesterol and triacylglycerol levels. While levels of A/G ratio, ALT and AST were highly decreased by both of N. sativa and TQ. Conclusion: These findings may rely on the lipid-modifying and hepatoprotective effects of N. sativa crude oil and its main constituent TQ on mammals. Thus, further investigations are required. | ||||
Keywords | ||||
Keywords: N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN); Sodium ascorbate (Na-As); Nigella sativa (N. sativa); Thymoquinone (TQ) | ||||
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