18F-FDG PET/CT Versus I-131 MIBG Scan in Diagnosis of Neuroblastoma Osseous Infiltrates; Comparative Study | ||||
| Egyptian Journal Nuclear Medicine | ||||
| Article 3, Volume 11, Issue 11, June 2015, Page 28-35 PDF (522.03 K) | ||||
| Document Type: Original Paper, Oncology | ||||
| DOI: 10.21608/egyjnm.2015.5446 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mai Amr  
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| Lecturer Of nuclear medicine, National Cancer Institute, Cairo University. | ||||
| Abstract | ||||
| Purpose: To compare diagnostic performance of 18F-FDG PET/CT & I-131 MIBG in neuroblastoma osseous lesions. Materials and method: cross sectional study with 63 pathologically proved NB patients with dominating high risk category (~65.1 %) who underwent paired F-18 FDG PET/CT and MIBG scans (with maximum 2 weeks interval) using standard techniques for purpose of initial , post-therapy or follow up assessment. Clinico-pathological, radiological and follow up data were also collected. Results: On lesion based analysis of neuroblastoma bone metastases, though nonoptimum sensitivity was noted with both modalities yet statistically significant higher sensitivity was seen with 18F-FDG PET/CT (73.1%) as compared to that of I-131 MIBG (55.2 %) (p- Value=0.03). Higher (nonstatistically significant) specificity of 100% was seen with I-131 MIBG compared to 92.5% for FDG PET/CT (p-value=0.95). Conclusion: FDG PET/CT scanning may have an added value in detection of NB osseous lesions compared to I-131 MIBG, which may help to guide BMB (Bone Marrow Biopsy) in patients with either (I-131 MIBG or 18F-FDG PET/CT) positive scans. | ||||
| Keywords | ||||
| FDG PET/CT; MIBG; Neuroblastoma osseous infiltrates | ||||
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