Hemin Ameliorated Letrozole-Induced Polycystic Ovary Syndrome: A Forward Step for Better Management | ||||
| The Medical Journal of Cairo University | ||||
| Article 151, Volume 87, June, June 2019, Page 2667-2678 PDF (1.04 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.54888 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| FATMA H. RIZK, M.D.; NEMA A. SOLIMAN, M.D.; AMIRA EL-SAADANY, M.D.; AL-SHIMAA ABO AL-SOUD, M.D.; MARWA A.A. IBRAHIM, M.D.; SHEREEF EL-SHWAIKH, M.D. | ||||
| The Departments of Physiology1, Medical Biochemistry2, Pharmacology3, Histology4 and Gynecology and Obstetrics5, Faculty of Medicine, Tanta University, Egypt | ||||
| Abstract | ||||
| Abstract Background: Previous studies showed that Heme Oxyge-nase-1 (HO-1) level was markedly reduced in Polycystic Ovary Syndrome (PCOS) which might highlight the role of HO-1system in the pathogenesis and treatment of PCOS. Aim of Study: The present study was done to study the effects of the induction of HO-1 system by hemin on Letrozole (LTZ)-induced PCOS in rats. Material and Methods: 40 female rats were divided into 4 equal groups; normal control (I), hemin (II), LTZ (III), hemin + LTZ treated (IV). Results: After three weeks, LTZ administration induced PCOS in female rats as evidenced by histological examination and biochemical analysis. It significantly increased testosterone level, LH and LH/FSH ratio compared with normal control group. LTZ significantly decreased plasma adiponectin level, ovarian Silent Information Regulator 1 level (SIRT1), Glu-tathione-S-Transeferase activity (GST), HO-1 mRNA expres-sion and ovarian B-Cell Lymphoma 2 (BCL2) expression compared with normal control group. While, it increased ovarian hydrogen peroxide (H2O2) level, ovarian BCL2 associated X (Bax) expression and Bax/Bcl2 ratio compared with normal control group. Hemin administration antagonized all these effects. Conclusion: We could conclude that, hemin is a promising drug for treatment of PCOS through its antioxidant, anti-inflammatory and anti-apoptotic effects which can rise up the possibility of involvement of HO system in pathogenesis of PCOS. | ||||
| Keywords | ||||
| Heme oxygenase-1 – Polycystic ovary syndrome – Letrozole | ||||
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