Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice
Abu-Dief, E., Mohammed, D., Abd El-Haliem, N., Mohammed, S., . El-Badry, A. (2017). Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice. EKB Journal Management System, 21(3), 525-529. doi: 10.21608/smj.2017.54986
Eman E Abu-Dief; Doha Mohammed; Nesreen Abd El-Haliem; Sherine Mohammed; Ashraf . El-Badry. "Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice". EKB Journal Management System, 21, 3, 2017, 525-529. doi: 10.21608/smj.2017.54986
Abu-Dief, E., Mohammed, D., Abd El-Haliem, N., Mohammed, S., . El-Badry, A. (2017). 'Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice', EKB Journal Management System, 21(3), pp. 525-529. doi: 10.21608/smj.2017.54986
Abu-Dief, E., Mohammed, D., Abd El-Haliem, N., Mohammed, S., . El-Badry, A. Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice. EKB Journal Management System, 2017; 21(3): 525-529. doi: 10.21608/smj.2017.54986

Quantitative Analysis of Reticular Fibers in CCl4-Induced Liver Cirrhosis in Mice

Sohag Medical Journal
Article 64, Volume 21, Issue 3, October 2017, Page 525-529  XML PDF (107.33 K)
Document Type: Original Article
DOI: 10.21608/smj.2017.54986
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Authors
Eman E Abu-Dief1; Doha Mohammed2; Nesreen Abd El-Haliem3; Sherine Mohammed3; Ashraf . El-Badry4
1Department of Histology, Faculty of Medicine, Sohag University, Egypt.
2Department of Histology, Faculty of Medicine, Sohag University, Egypt
3Department of histology, Faculty of medicine, Sohag university.
42Department of surgery, Faculty of medicine, Sohaguniversity
Abstract
Background
Cirrhosis is the final stage of chronic liver disease. It is characterized by diffuse fibrosis and disruption of hepatic lobular architectureinto abnormal cirrhotic nodules.
Aim of the work
This study was conducted to investigate the extent of reticular fibersdeposition in induced liver cirrhosis and their resolution after cessation of the insult.
Materials and methods
Three groups of animals were used; control, treated and recovery groups. The treatedgroup injected subcutaneously with CCl4 for 16 weeks for induction of cirrhosis, and the recovery group were kept for two weeks without injection after the 16 weeks of CCl4 treatment.
Results                                                                                                             
Our results indicated thatreticular fibers increased in liver cirrhosis and decreased with fibers resolution in mice.
Conclusion
Reticular fibers areinvolved in the process of fibrogenesis in mice and decreased in the resolution of fibers in the recovery of the model which can be consideredin newstudies for the treatment of liver cirrhosis.
Keywords
Cirrhosis; fibrosis; CCl4
Supplementary Files
References
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