The Possible Role of S100b Protein as A Prognostic Biomarker for Brain Injury in Acute Carbon Monoxide Poisoning | ||||
Mansoura Journal of Forensic Medicine and Clinical Toxicology | ||||
Article 1, Volume 19, Issue 1, January 2011, Page 1-16 PDF (33.14 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjfmct.2011.55318 | ||||
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Authors | ||||
Naila A. El Nayal1; Asmaa A. Fawzy1; Hanan F. Abd El-Aziz1; Heba Y. Mohamed1; Hany M. Tawfik2 | ||||
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain Shams University, Egypt | ||||
2Poison Control Center, Faculty of Medicine, Ain Shams University, Egypt | ||||
Abstract | ||||
The current study was carried out on sixty two carbon monoxide (CO) poisoned patients admitted to Poison Control Center Ain Shams University (PCCA), from January 2008 to June 2009. Patients were divided into four groups: Group I: twenty patients (mild CO poisoning). Group II: fifteen patients (moderate CO poisoning). Group III: twenty seven patients (severe CO poisoning). Group IV (control): fifteen healthy non-smokers. Serum S100B protein, blood CO level, random blood sugar (RBS) and arterial blood PH were assessed in all groups. Highly significant increase in serum S100B protein was found in all studied patients in comparison with the control. Patients who developped neurological sequelae had significantly high S100B protein. Blood CO level was significantly high in all tested groups. There was also highly significant increase in RBS in group III only. In addition, there was significant increase in the RBS in patients who died and in those with neurological sequelae. It can be concluded that protein S100B may be used as a useful biomarker of brain damage in acute CO poisoning and is helpful in assessment of its severity and prediction of neurological sequelae and mortality. | ||||
Keywords | ||||
Protein S100B; Acute CO Poisoning; Brain Injury | ||||
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