Assessment of urinary kidney injury molecule-1 in children with iron deficiency anemia | ||||
| Zagazig University Medical Journal | ||||
| Article 284, Volume 27, Issue 3, May 2021, Page 485-491 PDF (550.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2019.16662.1496 | ||||
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| Authors | ||||
shaaban elsayed  1; Naglaa Khalifa2; mohammed abd elsalam3
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| 1Pediatric Department, Al-Ahrar Teaching Hospital, Sharkia, Egypt | ||||
| 2Faculty of Medicine, Zagazig University, Department of Clinical Pathology, Sharkia, Egypt | ||||
| 3Faculty of Medicine, Zagazig University, Department of Pediatrics, Sharkia, Egypt | ||||
| Abstract | ||||
| ABSTRACT Background: Iron deficiency anemia (IDA) is a common type of anemia during childhood that can cause tissue hypoxia which plays a major role in acute kidney injury (AKI). Aim of the study: Assessment of urinary kidney injury molecule-1 in children with iron deficiency anemia for early detection of kidney injury. Methods: This case control study was done at pediatric departmet of Zagazig uiversity hospitals where 23 children with IDA , 23 matched healthy controls were recruited , we assessed complete blood count (CBC), serum iron , total iron binding capacity, ferritin, serum levels of creatinine(Cr) , urea , sreum electrolytes sodium (Na), potassium(K), calcium (Ca), blood glucose levels, c-reactive protien (CRP). Urinary KIM-1 levels were measured and divided by urine creatinine . Results: Our study showed no statistically significant differences in biochemical characteristics, serum creatinine and urea of the studied children of both case and control groups (P>0.05). Children with IDA had statistically significantly higher KIM-1/Cr ratio than control group (P | ||||
| Keywords | ||||
| Keywords: Anemia; kidney; iron; Kim-1; creatinine | ||||
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