Hepatitis B Virus: Update in Management | ||||
| Medical Journal of Viral Hepatitis | ||||
| Article 3, Volume 3.2, Issue 2, April 2019, Page 49-56 PDF (250.35 K) | ||||
| Document Type: Review articles | ||||
| DOI: 10.21608/mjvh.2019.55730 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Abdelhamed Mohamed1; El Badawy Reda1; Abdelaziz Mohamed2; Mousa Nasser2 | ||||
| 1Hepatology dept., Gastroenterology & infectious disease, Faculty of Medicine, Benha Univ., Egypt | ||||
| 2Tropical Medicine dept., Faculty of Medicine, Mansoura Univ., Egypt | ||||
| Abstract | ||||
| Hepatitis B virus (HBV) infection is a major public health problem worldwide. HBV, a member of the hepadnaviridae family, is a small DNA replicates through an RNA intermediate and can integrate into the host genome. It is transmitted through contact with infected blood and semen. HBV infection leads to a wide spectrum of liver disease ranging from acute - fulminant hepatic failure to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Infants and children are more likely to develop a chronic hepatitis B infection, while most adults infected with the virus recover even if their signs and symptoms are severe, but 5%- 10% are unable to clear the virus and become chronically infected. Screening for HBV infection could identify chronically infected persons who may benefit from treatment or other interventions, such as surveillance for hepatocellular carcinoma. Most people diagnosed with chronic hepatitis B infection need treatment for the rest of their lives. The primary treatment goals for patients with HBV infection are to prevent progression of the disease to cirrhosis, liver failure, and hepatocellular carcinoma. Moreover, prevents infection from passing to others. Treatment for chronic hepatitis B may include several antiviral medications such as, entecavir, tenofovir, lamivudine, adefovir and telbivudine. These drugs can help fight the virus and slow its ability to damage your liver. WHO recommends that all infants receive the hepatitis B vaccine as soon as possible after birth, preferably within 24 hours? | ||||
| Keywords | ||||
| Hepatitis B virus; Nucleoside/nucleotide analogues and hepatitis B vaccine | ||||
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