The role of interleukin-2 and interleukin-4 in disease progression in patients with schistosomiasis combined with chronic viral hepatitis C and chronic viral hepatitis B | ||||
| Medical Journal of Viral Hepatitis | ||||
| Article 4, Volume 3.2, Issue 2, April 2019, Page 57-64 PDF (156.23 K) | ||||
| Document Type: Original article | ||||
| DOI: 10.21608/mjvh.2019.55731 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mousa Nasser1; Abdel-Razik Ahmed1; Talat qattan Ilham2; sheta Tarek3; Rizk Hassan4; Deiab Ahmed4; Elshazly Atef5; Elshinawy Farha6 | ||||
| 1Tropical Medicine dept, Faculty of Medicine, Mansoura Univ., Egypt. | ||||
| 2Medical Molecular Virology, Taibah University, KSA | ||||
| 3Internal Medicine dept., Faculty of Medicine, Mansoura Univ., Egypt. | ||||
| 4Internal Medicine dept., Faculty of Medicine, Mansoura Univ., Egypt | ||||
| 5Parasitology dept., Faculty of Medicine, Mansoura Univ., Egypt. | ||||
| 6Clinical pathology dept., ., Faculty of Medicine, Mansoura Univ., Egypt. | ||||
| Abstract | ||||
| Background: Schistosomiasis remains an important cause of parasitic morbidity and mortality worldwide. In countries where schistosomiasis is endemic, a high prevalence of combined Schistosomiasis mansoni and chronic hepatitis C and chronic hepatitis B co-infection has been described. The immunopathogenesis of human schistosomiasis with or without chronic hepatitis remains controversial. Aim of the work: Is to evaluate the immunopathogenic role of Th1 cytokine (IL-2) and Th2 cytokine (IL-4) in patients with different stages of hepatointestinal schistosomiasis with or without chronic hepatitis. Methods: The study included 60 Egyptian patients with different stages of hepatointestinal schistosomiasis. They include 40 patients with hepatosplenic schistosomiasis (divided into 4 subgroups according to stage of hepatosplenic schistosomiasis), 10 patients with schistosoma mansoni and chronic hepatitis C and 10 patients with schistosoma mansoni and chronic hepatitis B co-infection, In addition to, 10 healthy controls. IL-2 and Il-4 was measured by competitive enzyme immunoassay (EIA) which measures the natural and recombinant forms of the cytokines. Results: Compared to control group, patients with hepatosplenic schistosomiasis showed significant increase in serum IL-2 from stage 1 (P< 0.05) to stage 4 (P< 0.001). Moreover, both groups with combined schistosomiasis and chronic hepatitis C and chronic hepatitis B showed significant increase in the IL-2 (P< 0.05 for both). Furthermore, decompensated schistosomiasis showed highly significant increase in the IL-2 versus compensated schistosomiasis (P< 0.001). Also, compared to control group, patients with hepatosplenic schistosomiasis showed significant increase in serum IL-4, that decreased from stage 1 (P< 0.001)) to nonsignificant increase in stage 4 (P> 0.05). In addition, chronic HCV with schistosomiasis showed significant increase in the IL-4 (P< 0.05) and chronic HBV with schistosomiasis showing significant increase in the IL-4 (P< 0.001). Moreover, compensated schistosomiasis showed significant increase in the IL-4 (P< 0.001) versus decompensated schistosomiasis. Conclusion: Patients with chronic schistosomiasis present a mixed profile of Th1 and Th2 cytokines. The Th1 (IL-2) was increased with the progression of the hepatosplenic schistosomiasis from stage 1(hepatomegaly) to the stage 4. However, The Th2 (IL-4) was elevated in the first stage of hepstosplenic schistosomiasis and then decreased with progression of the disease. In patients with combined schistosomiasis and chronic hepatitis the Th2 (IL-4) is the predominant cytokine versusTh1 (IL-2). | ||||
| Keywords | ||||
| Schistosomiasis; Chronic hepatitis; interleukin-2 and interleukin-4 | ||||
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