B-cell monoclonal lymphocytosis in chronic hepatitis C virus infection | ||||
| Medical Journal of Viral Hepatitis | ||||
| Article 5, Volume 3.1, Issue 1, November 2018, Page 27-35 PDF (193.59 K) | ||||
| Document Type: Original article | ||||
| DOI: 10.21608/mjvh.2018.55753 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mousa Nasser1; Alfar Marwa2; Abd El- Maksoud Mohamed2 | ||||
| 1Tropical Medicine dept, Faculty of Medicine, Mansoura Univ., Egypt. | ||||
| 2Tropical Medicine dept, Faculty of Medicine, Mansoura Univ., Egypt | ||||
| Abstract | ||||
| Background: Clinical data document the connection between hepatitis C virus (HCV) and B cell proliferative. Monoclonal B lymphocytosis (MBL) is an asymptomatic condition characterized by the presence in the peripheral blood of a clonal Bcell population which might evolve into malignant B cell lymphoproliferative disease, like chronic lymphocytic leukemia or indulant B cell lymphoma. The underlying association between HCV and MBL is not yet understood. Aim of the work: To evaluate the presence of monoclonal B lymphocytosis in patients with chronic hepatitis C with various activity and severity according to METAVIR Scoring System. Methods: The study included one hundred patients with chronic HCV infection and forty healthy controls. Liver biopsy was done for patient's group and analyzed according to METAVIR Scoring System. Flow cytometric analysis for B-cell monoclonal lymphocytosis was done for both patients and control groups. Results: MBL were identified in 24/100 (24%) in patients with chronic HCV at significantly higher frequency versus in the control group 3/40 (7.5%). No significant difference regarding MBL was found between early (F1-F2) and late (F3-F4) fibrosis subgroups; however, MBL expression was significantly higher in A1 when compared to A2 and A3 activity grads. Concerning laboratory data there was no significant difference between patients with MBL and patients without MBL apart from significant increase in total leucocyte count in patients without MBL. Also the age was significantly increased in MBL positive patients versus MBL negative patients. Conclusions: B-cell monoclonal lymphocytosis showed significant increase in HCV infected patients more than in the general population. No significant differences in MBL expression between early and advanced fibrosis stage however, MBL expression was significantly higher in A1 versus A2 and A3activety grads. | ||||
| Keywords | ||||
| B-cell monoclonal lymphocytosis; chronic hepatitis C infection; Liver Biopsy; Liver fibrosis | ||||
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